Evidence map›Paper›PMID 32350163›Full record

ArticleAnnals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia2020

Gender Differences in Predictors and Long-Term Mortality of New-Onset Postoperative Atrial Fibrillation Following Isolated Aortic Valve Replacement Surgery.

Mariana Fragão-Marques, Jennifer Mancio, João Oliveira, Inês Falcão-Pires, Adelino Leite-Moreira

3 registry-linked trialsOpen access · goldAbstract readComparative Study
In one paragraph

Article in Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05062239 narecruitingnot on this mapstarted 2022, after this paper: background citation

Post-Operative Atrial Fibrillation After Surgical Aortic Valve Replacement and the Influence of Statins - Randomized Controlled Trial

TypeinterventionalSponsorLars Peter RiberRan2022 to 2027Enrolled100ConditionsPostoperative Atrial FibrillationArmsDiscontinuance of treatment with statins 7 to 14 days prior to surgery until 30 days postoperative, No-intervention.
NCT05076019 narecruitingnot on this mapstarted 2022, after this paper: background citation

Statin Therapy With Atorvastatin in Surgical Aortic Valve Replacement - a Randomized Controlled Trial

TypeinterventionalSponsorOdense University HospitalRan2022 to 2027Enrolled266ConditionsPostoperative Atrial FibrillationArmsAtorvastatin 80mg, Placebo
NCT06800781 narecruitingnot on this mapstarted 2025, after this paper: background citation

Prolonged Posterior Pericardial Chest Tube Treatment to Reduce Rates of Postoperative Atrial Fibrillation Following Cardiac Surgery

TypeinterventionalSponsorRegion SkaneRan2025 to 2033Enrolled624ConditionsCoronary Arterial Disease (CAD), Valve Replacement, Aortic SurgeryArmsProlonged treatment with posterior pericardial chest tube plus standard care
3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. The influence of sex on early post-operative atrial fibrillation after cardiac surgery.Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc · 2023
    Article
  6. Article
  7. Review
  8. Article
  9. Sex-Specific Features of Calcific Aortic Valve Disease.International journal of molecular sciences · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Mariana Fragão-MarquesDepartment of Surgery and Physiology, Faculty of Medicine, University of Porto, Portugal.
Jennifer MancioDepartment of Surgery and Physiology, Faculty of Medicine, University of Porto, Portugal.
João OliveiraDepartment of Surgery and Physiology, Faculty of Medicine, University of Porto, Portugal.
Inês Falcão-PiresDepartment of Surgery and Physiology, Faculty of Medicine, University of Porto, Portugal.
Adelino Leite-MoreiraDepartment of Surgery and Physiology, Faculty of Medicine, University of Porto, Portugal.
Universidade do Porto · PTHospital de São João · PT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposePostoperative atrial fibrillation (POAF) after coronary artery bypass grafting (CABG) has been associated with increased risk of death in women but not in men. We aimed to explore predictors and long-term mortality in POAF following isolated aortic valve replacement (AVR) surgery in men and women.

methodsThis study included 379 severe aortic stenosis patients with no prior atrial fibrillation (AF) who underwent isolated AVR surgery. We used multiple logistic regression to investigate independent gender-specific predictors of new-onset POAF, and we performed Kaplan-Meier (KM) to determine the impact of POAF in long-term mortality according to gender.

resultsAdvanced age and coronary artery disease prevalence were higher among POAF patients in both genders. On multiple analysis, increased postoperative peak lactate was independently associated with POAF in men, while lower mean aortic valve gradient was associated with POAF in women. Area under the curve (AUC) for the model was 0.77 [0.68-0.86] and 0.69 [0.60-0.78] for men and women, respectively. At 4-year follow-up, POAF was linked to increased risk of death in men but not in women.

conclusionIn severe aortic stenosis, factors associated with POAF and its impact on mortality differed between genders, with an increased risk of death observed only in men.

Indexed as

AgedAged, 80 and overAortic ValveAortic Valve StenosisAtrial FibrillationFemaleHeart Valve Prosthesis ImplantationHospital MortalityHumansMaleMiddle AgedRetrospective StudiesRisk AssessmentRisk FactorsSeverity of Illness IndexSex Factorsaortic stenosisgendermortalitypostoperative atrial fibrillationrisk factors

Identifiers

PMID32350163
PMCPMC7801179
OpenAlexW3017856706

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.