ArticleProceedings of the National Academy of Sciences of the United States of America2020
The Great Oxidation Event expanded the genetic repertoire of arsenic metabolism and cycling.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers.
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Who cites it
64 citing papers in PubMed, 177 citations in OpenAlex.
- Arsenic-sensing domain controls ACR3 transporter trafficking in Marchantia polymorpha.The Plant cell · 2026Article
- Evolutionary trajectory of microbial sulfur oxidation pathways recapitulates Earth's oxygenation history.Nature communications · 2026Article
- Abiotic sources of fixed nitrogen sustained early ecosystems for several hundred million years after the origin of life.Science advances · 2026Article
- Synergistic function of ars genes in arsenic detoxification and biosynthesis of organoarsenicals.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2026Review
- Redox robustness drives LPMO evolution.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Arsenic-cycling metabolism recorded in hot spring silica deposits.Communications earth & environment · 2026Article
- Iron binding before iron limitation: siderophore synthesis arose well before iron became a limiting element.ISME communications · 2026Article
- Decoding microbial diversity, biogeochemical functions, and interaction potentials in red sea hydrothermal vents.Environmental microbiome · 2025Article
- Rhizosphere Microbiome-Root Exudate Synergy in Pteris vittata: Coordinated Arsenic Speciation and Multielement Metabolic Coupling Drive Hyperaccumulation Efficiency.Microbial ecology · 2025Article
- Reaction Mechanism and Metal Selectivity of Human SAMHD1 Elucidated by QM/MM Calculations.ACS catalysis · 2025Article
- Review
- A battle against arsenic toxicity by Earth's earliest complex life forms.Nature communications · 2025Article
- Rhizosphere-triggered viral lysogeny mediates microbial metabolic reprogramming to enhance arsenic oxidation.Nature communications · 2025Article
- Augmenting Cr(VI) phytoremediation potential of Ricinus communis through rhizospheric crosstalk with multi stress tolerant plant growth promoting Bacillus altitudinis M1.World journal of microbiology & biotechnology · 2025Article
- Biosensor-aided isolation of anaerobic arsenic-methylating bacteria from soil.ISME communications · 2025Article
- Distinct bacterial community structures and arsenic biotransformation gene profiles in dust.Frontiers in microbiology · 2025Article
- Comparative impacts of polyethylene and biodegradable film residues on soil microbial communities and rapeseed performance under field conditions.Frontiers in microbiology · 2025Article
- Growth substrate limitation enhances anaerobic arsenic methylation byApplied and environmental microbiology · 2024Article
- Adaptive expression of phage auxiliary metabolic genes in paddy soils and their contribution toward global carbon sequestration.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Various microbial taxa couple arsenic transformation to nitrogen and carbon cycling in paddy soils.Microbiome · 2024Article
4 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
12 authors at 5 institutions in 3 countries.
Funding
Abstract
The rise of oxygen on the early Earth about 2.4 billion years ago reorganized the redox cycle of harmful metal(loids), including that of arsenic, which doubtlessly imposed substantial barriers to the physiology and diversification of life. Evaluating the adaptive biological responses to these environmental challenges is inherently difficult because of the paucity of fossil records. Here we applied molecular clock analyses to 13 gene families participating in principal pathways of arsenic resistance and cycling, to explore the nature of early arsenic biogeocycles and decipher feedbacks associated with planetary oxygenation. Our results reveal the advent of nascent arsenic resistance systems under the anoxic environment predating the Great Oxidation Event (GOE), with the primary function of detoxifying reduced arsenic compounds that were abundant in Archean environments. To cope with the increased toxicity of oxidized arsenic species that occurred as oxygen built up in Earth's atmosphere, we found that parts of preexisting detoxification systems for trivalent arsenicals were merged with newly emerged pathways that originated via convergent evolution. Further expansion of arsenic resistance systems was made feasible by incorporation of oxygen-dependent enzymatic pathways into the detoxification network. These genetic innovations, together with adaptive responses to other redox-sensitive metals, provided organisms with novel mechanisms for adaption to changes in global biogeocycles that emerged as a consequence of the GOE.
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Registered trials
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