Evidence map›Paper›PMID 32350138›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2020

Characterization of the coformycin biosynthetic gene cluster in

Daan Ren, Mark W Ruszczycky, Yeonjin Ko, Shao-An Wang, Yasushi Ogasawara, Minje Kim, Hung-Wen Liu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
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  3. Review
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  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Daan RenDepartment of Chemistry, University of Texas at Austin, Austin, TX 78712.
Mark W RuszczyckyDivision of Chemical Biology and Medicinal Chemistry, College of Pharmacy, University of Texas at Austin, Austin, TX 78712.
Yeonjin KoDepartment of Chemistry, University of Texas at Austin, Austin, TX 78712.
Shao-An WangDepartment of Chemistry, University of Texas at Austin, Austin, TX 78712.
Yasushi OgasawaraDivision of Chemical Biology and Medicinal Chemistry, College of Pharmacy, University of Texas at Austin, Austin, TX 78712.ORCID 0000-0002-3144-3985
Minje KimDepartment of Chemistry, University of Texas at Austin, Austin, TX 78712.
Hung-Wen LiuDepartment of Chemistry, University of Texas at Austin, Austin, TX 78712; h.w.liu@mail.utexas.edu.ORCID 0000-0001-8953-4794

Funding

Mechanistic Studies of Deoxy Sugar BiosynthesisR01GM035906 · NIGMS · UNIVERSITY OF TEXAS AT AUSTIN · PI LIU, HUNG-WEN · 1986 to 2023
$6.1M
MECHANISMS OF BIOSYNTHETIC FORMATION OF DEOXY SUGARSR37GM035906 · NIGMS · UNIVERSITY OF TEXAS AUSTIN · PI LIU, HUNG-WEN · 1999 to 2008
$3.4M
Bruker AVANCE III HD 500 MHz NMRS10OD021508 · OD · UNIVERSITY OF TEXAS AT AUSTIN · PI SESSLER, JONATHAN L · 2016 to 2016
$529k
NIGMS NIH HHS R01 GM035906NIGMS NIH HHS R37 GM035906NIH HHS S10 OD021508
6 · The paper itself

Abstract

Coformycin and pentostatin are structurally related N-nucleoside inhibitors of adenosine deaminase characterized by an unusual 1,3-diazepine nucleobase. Herein, the

Indexed as

Multigene FamilyAdenosine DeaminaseAdenosine MonophosphateAdenosine TriphosphateBacterial ProteinsBiosynthetic PathwaysCoformycinPhosphorylationStreptomycesAdenosine DeaminaseAdenosine MonophosphateAdenosine TriphosphateBacterial ProteinsCoformycincoformycindiazepine biosynthesishistidinepentostatinSAICAR

Identifiers

PMID32350138
PMCPMC7229688

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.