ArticleDiabetes care2020
Strict Preanalytical Oral Glucose Tolerance Test Blood Sample Handling Is Essential for Diagnosing Gestational Diabetes Mellitus.
Article in Diabetes care, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
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Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 68 citations in OpenAlex.
- The association of serum total bile acid levels with gestational diabetes mellitus: a systematic review and meta-analysis.BMC pregnancy and childbirth · 2024Pooled it
- Early Pregnancy Glycemic Testing for Prediction of Gestational Diabetes Mellitus and Large-for-Gestational-Age Birth Weight.Diabetes care · 2026Observational
- Mild and non-persistent fasting plasma glucose elevation in the first trimester of pregnancy is not associated with increased risk of gestational diabetes mellitus and adverse pregnancy outcomes.Archives of endocrinology and metabolism · 2026Article
- First-Trimester Gestational Diabetes Mellitus Risk Prediction with Machine Learning Techniques: Results from the BORN2020 Cohort Study.Journal of clinical medicine · 2026Article
- Use of the GTT@home Oral Glucose Tolerance Test Kit in Gestational Diabetes Mellitus: Performance Evaluation Study.JMIR diabetes · 2026Article
- Sucralose Exposure During Pregnancy Elevates Gestational Diabetes Risk via Gut Microbiota-Metabolic Axis in Mice.Journal of diabetes research · 2026Article
- Fasting Metabolite Panel for OGTT-Free Diagnosis of Gestational Diabetes Mellitus: A Machine Learning Approach Validated in Dual Cohorts.Diabetes, metabolic syndrome and obesity : targets and therapy · 2026Article
- Impact of time from blood specimens collection to centrifugation on the diagnosis of gestational diabetes mellitus.Annals of medicine · 2025Article
- Hyperglycaemia in pregnancy: the role of ethnicity and geography in risk and outcomes.Diabetologia · 2025Review
- Gestational age and models for predicting gestational diabetes mellitus.Metabolomics : Official journal of the Metabolomic Society · 2025Observational
- Australasian Diabetes in Pregnancy Society (ADIPS) 2025 consensus recommendations for the screening, diagnosis and classification of gestational diabetes.The Medical journal of Australia · 2025Article
- Enhanced glucose processing in gestational diabetes diagnosis: Effects on health equity and clinical outcomes.Diabetic medicine : a journal of the British Diabetic Association · 2025Observational
- Relationship Between 1,5 Anhydroglucitol, Glycemia, and Breastfeeding During Pregnancy and Postpartum: A Pilot Study.Journal of the Endocrine Society · 2024Article
- The Association between Gut Microbiota and Its Metabolites in Gestational Diabetes Mellitus.Journal of microbiology and biotechnology · 2024Article
- Article
- Observational
- Development of machine learning models to predict gestational diabetes risk in the first half of pregnancy.BMC pregnancy and childbirth · 2023Article
- One-Hour Post-Load Plasma Glucose and Altered Glucometabolic Profile in Youths with Overweight or Obesity.International journal of environmental research and public health · 2023Article
- Interactive effects of gestational diabetes mellitus and maximum level of total bile acid in maternal serum on adverse pregnancy outcomes in women with intrahepatic cholestasis of pregnancy.BMC pregnancy and childbirth · 2023Observational
- A Clinical Update on Gestational Diabetes Mellitus.Endocrine reviews · 2022Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivePreanalytical processing of blood samples can affect plasma glucose measurement because ongoing glycolysis by cells prior to centrifugation can lower its concentration. In June 2017, ACT Pathology changed the processing of oral glucose tolerance test (OGTT) blood samples for pregnant women from a delayed to an early centrifugation protocol. The effect of this change on the rate of gestational diabetes mellitus (GDM) diagnosis was determined. RESEARCH DESIGN AND
methodsAll pregnant women in the Australian Capital Territory (ACT) are recommended for GDM testing with a 75-g OGTT using the World Health Organization diagnostic criteria. From January 2015 to May 2017, OGTT samples were collected into sodium fluoride (NaF) tubes and kept at room temperature until completion of the test (delayed centrifugation). From June 2017 to October 2018, OGTT samples in NaF tubes were centrifuged within 10 min (early centrifugation).
resultsA total of 7,509 women were tested with the delayed centrifugation protocol and 4,808 with the early centrifugation protocol. The mean glucose concentrations for the fasting, 1-h, and 2-h OGTT samples were, respectively, 0.24 mmol/L (5.4%), 0.34 mmol/L (4.9%), and 0.16 mmol/L (2.3%) higher using the early centrifugation protocol (
conclusionsThe findings of this study highlight the critical importance of the preanalytical processing protocol of OGTT blood samples used for diagnosing GDM. Delay in centrifuging of blood collected into NaF tubes will result in substantially lower rates of diagnosis than if blood is centrifuged early.
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