Evidence map›Paper›PMID 32349855›Full record

SynthesisPublic health nutrition2020

Relationship between gestational acrylamide exposure and offspring's growth: a systematic review and meta-analysis of cohort studies.

Yongle Zhan, Ying Xiao, Tianjia Guan, Shuyang Zhang, Yu Jiang

Abstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in Public health nutrition, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. FIGO committee opinion: Environmental drivers of obstetric health and early childhood development.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2025
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yongle Zhan *School of Public Health, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing100730, China.
Ying Xiao *Department of Cardiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing100005, China.
Tianjia GuanSchool of Public Health, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing100730, China.
Shuyang ZhangDepartment of Cardiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing100005, China.
Yu JiangSchool of Public Health, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing100730, China.ORCID 0000-0002-2443-911X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo estimate the current evidence regarding the association between gestational acrylamide (AA) exposure and offspring's growth.

designSystematic review and meta-analysis.

settingA systematic literature search for relevant publications was conducted using PubMed, Medline, Embase, Web of Science databases from inception to 26 April 2019. The standardised mean difference (SMD) or OR with 95 % CI was selected as the effect sizes and was calculated using a random effects model.

resultsFive cohort studies including 54 728 participants were identified. Offspring's birth weight was significantly lower in high AA exposure group than in low AA exposure group (SMD -0·05, 95 % CI -0·09, -0·02, P = 0·005). There was also an association between maternal AA exposure and small for gestational age (OR 1·14, 95 % CI 1·06, 1·23, P < 0·001). In addition, pooled ORs suggested that children had a high risk of developing overweight/obesity in the future in maternal high AA exposure group (OR 1·14, 95 % CI 1·08, 1·21, P < 0·001 at age 3; OR 1·13, 95 % CI 1·07, 1·19, P < 0·001 at age 5; OR 1·09, 95 % CI 1·02, 1·16, P = 0·020 at age 8).

conclusionsThese findings have important implications for conducting health education, providing guidance on maternal diet and developing an appropriate dietary strategy for pregnant women to reduce dietary AA exposure.

Indexed as

AcrylamideAdultBirth WeightDietary ExposureFemaleHumansInfantInfant, NewbornInfant, Small for Gestational AgeMaleMaternal ExposureMaternal Nutritional Physiological PhenomenaOdds RatioPediatric ObesityPregnancyPrenatal Exposure Delayed EffectsAcrylamideAcrylamideGestationalGrowthOffspring

Identifiers

PMID32349855
PMCPMC10200512

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.