ArticleBMC oral health2020
Comparison of microbiomes in ulcerative and normal mucosa of recurrent aphthous stomatitis (RAS)-affected patients.
Article in BMC oral health, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 47 citations in OpenAlex.
- How Nutrient Deficiencies Impact the Oral Mucosa and How to Manage Them: A Narrative Review.Nutrients · 2026Review
- Unraveling Oral Dysbiosis: Microbial Complexity in Common Oral Diseases.MicrobiologyOpen · 2026Review
- Oral Microbiome Dynamics in Patients with Acute Lymphoblastic Leukemia and Oral Mucositis.Microorganisms · 2026Article
- Prevalence, risk factors, and psychosocial impact of self-reported recurrent oral ulceration among Palestinian medical and dental students: a multicenter cross-sectional study.BMC oral health · 2026Article
- Effects of glycyrrhizin on healing and prevention of recurrent aphthous stomatitis in hamster models.PloS one · 2026Article
- Analysis of Oral Microbiota in Herpetiform Aphthous Ulcers Patients.Oral health & preventive dentistry · 2025Article
- Salivary Protein Profile in Patients with Recurrent Aphthous Stomatitis: A Pilot Proteomic Study.International journal of molecular sciences · 2025Article
- Anxiety and small intestinal bacterial overgrowth: associations with recurrent aphthous ulcers.BMC oral health · 2025Article
- Aphthous stomatitis - computational biology suggests external biotic stimulus and immunogenic cell death involved.BMC oral health · 2024Article
- Genetic Connectivity of Gut Microbiota and Oral Ulcers: A Mendelian Randomization Study.International dental journal · 2024Article
- Article
- Multifunctional polysaccharide composited microneedle for oral ulcers healing.Materials today. Bio · 2023Article
- Promoting oral mucosal wound healing using a DCS-RuBBioactive materials · 2023Article
- [Research Progress in Oral Diseases and Oral Microbiota of Organ Transplant Patients].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2023Review
- The Oral Microbiota: Community Composition, Influencing Factors, Pathogenesis, and Interventions.Frontiers in microbiology · 2022Review
- Detection and Analysis of the Oral Flora in Patients with Recurrent Aphthous Stomatitis.Evidence-based complementary and alternative medicine : eCAM · 2022Article
- Review
- A metagenome-wide association study of the gut microbiota in recurrent aphthous ulcer and regulation by thalidomide.Frontiers in immunology · 2022Article
- Crosstalk between the oral microbiota, mucosal immunity, and the epithelial barrier regulates oral mucosal disease pathogenesis.Mucosal immunology · 2021Review
- Salivary proteome of aphthous stomatitis reveals the participation of vitamin metabolism, nutrients, and bacteria.Scientific reports · 2021Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundRecurrent aphthous stomatitis (RAS) is the most common form of oral ulcerative disease, whose cause is still unknown. Researchers have found the association of many factors with the occurrence of RAS, and proposed oral bacterial infection could be a cause for this disease.
methodsTo investigate whether the occurrence of RAS is associated with oral bacterial infection, we performed high throughput sequencing analysis of bacterial samples collected from the normal oral mucosa and aphthous ulcers of 24 patients.
resultsFirmicutes, Proteobacteria and Bacteriodetes were the most abundant phyla in the microbiomes analysed. The alpha diversities of the oral mucosa and aphthous ulcer microbiomes were similar, suggesting a similar richness and diversity. The NMDS analysis showed the oral mucosa and aphthous ulcer microbiomes are significantly different. This suggestion is further supported by Anosim, MRPP, and Adonis analyses. More detailed comparison of the two groups of microbiomes suggested that the occurrence of RAS is significantly associated with the increase of Escherichia coli and Alloprevotella, as well as the decrease of Streptococcus.
conclusionsConsidering E. coli is a very common intestinal bacterium, we propose that E. coli colonization could be a cause for RAS, and controlling E. coli colonization could help curing RAS.
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Registered trials
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