Evidence map›Paper›PMID 32349713›Full record

ArticleBMC cancer2020

Pretreatment elevated prognostic nutritional index predicts a favorable prognosis in patients with prostate cancer.

Bin Li, Zheng Lu, Shengzheng Wang, Junqing Hou, Gang Xia, Heng Li, Bo Yin, Wei Lu

Open access · goldAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC cancer, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 5 pooled it
2.8field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 5 syntheses or guidelines pooled it, 49 citations in OpenAlex.

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  7. [The value of the nutritional assessment index or score in prognostic evaluation for patients with liver cancer].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Bin LiDepartment of Urology, Xinyang Central Hospital, 1 Siyi Road, Shihe District, Xinyang, Henan, 464000, People's Republic of China.
Zheng LuDepartment of Urology, Xinyang Central Hospital, 1 Siyi Road, Shihe District, Xinyang, Henan, 464000, People's Republic of China.
Shengzheng WangDepartment of Urology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Junqing HouClinical Medical College of Henan University, Kaifeng, Henan, China.
Gang XiaDepartment of Urology, Xinyang Central Hospital, 1 Siyi Road, Shihe District, Xinyang, Henan, 464000, People's Republic of China.
Heng LiDepartment of Urology, Xinyang Central Hospital, 1 Siyi Road, Shihe District, Xinyang, Henan, 464000, People's Republic of China.
Bo YinDepartment of Urology, Xinyang Central Hospital, 1 Siyi Road, Shihe District, Xinyang, Henan, 464000, People's Republic of China.
Wei LuDepartment of Urology, Xinyang Central Hospital, 1 Siyi Road, Shihe District, Xinyang, Henan, 464000, People's Republic of China. luweimed@163.com.ORCID http://orcid.org/0000-0001-6544-0208
Xinyang Central Hospital · CNHenan University · CNFirst Affiliated Hospital of Zhengzhou University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe prognostic nutritional index (PNI), an immunity and nutrition based prognostic score, was correlated with clinical outcomes in different tumors. However, the prognostic significance of PNI has not been investigated in hormone sensitive prostate cancer (PCa). The objective of this study was to determine the prognostic significance of PNI in hormone sensitive PCa.

methodsTwo hundred eighty PCa patients undergoing androgen deprivation therapy (ADT) as first line therapy at three centers were enrolled. The serum albumin levels and peripheral lymphocyte count were measured at the time of diagnosis. PNI was calculated as 10 * serum albumin (g/dL) + 0.005 * total lymphocyte count (per mm3). Patients were categorized in two groups using a cut-off point of 50.2 as calculated by the receiver-operating curve analysis. Univariate and multivariate cox regression analyses were performed to evaluate PNI as a favorable prognostic factor for progression-free survival (PFS), cancer-specific survival (CSS) and overall survival (OS). Prognostic accuracy was evaluated with the Harrell concordance index.

resultsMultivariate analyses identified PNI as an independent prognostic indicator with respect to PFS (hazard ratio (HR) = 0.521, p = 0.001), CSS (HR = 0.421, p = 0.002) and OS (HR = 0.429, p = 0.001). Patients with elevated PNI had better clinical outcomes. The addition of PNI to the final models improved predictive accuracy (c-index: 0.758, 0.830 and 0.782) for PFS, CSS and OS compared with the clinicopathological base models (c-index: 0.736, 0.801 and 0.752), which included Gleason score and incidence of metastasis.

conclusionsElevated pretreatment PNI was a favorable prognostic indicator for PCa patients treated with ADT.

Indexed as

Nutritional StatusNutrition AssessmentAdultAgedAndrogen AntagonistsFollow-Up StudiesHumansLymphocyte CountMaleMiddle AgedNeoplasms, Hormone-DependentPredictive Value of TestsPrognosisProstatic NeoplasmsRetrospective StudiesSerum Albumin, HumanAndrogen AntagonistsSerum Albumin, HumanPrognostic factorPrognostic nutritional indexProstate cancerSurvival

Identifiers

PMID32349713
PMCPMC7191702
OpenAlexW3021602304

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.