Evidence map›Paper›PMID 32349697›Full record

ArticleBMC psychiatry2020

Circadian rhythm and sleep alterations in older people with lifetime depression: a case-control study.

Camilla M Hoyos, Christopher Gordon, Zoe Terpening, Louisa Norrie, Simon J G Lewis, Ian B Hickie, Sharon L Naismith

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC psychiatry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 3 pooled it
6.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 3 syntheses or guidelines pooled it, 49 citations in OpenAlex.

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  16. 24-Hour Rest-Activity Rhythm in Middle-Aged and Older Persons with Depression.International journal of environmental research and public health · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Camilla M HoyosThe University of Sydney, Faculty of Science, School of Psychology, Sydney, NSW, Australia. camilla.hoyos@sydney.edu.au.
Christopher GordonCIRUS, Centre for Sleep and Chronobiology, Woolcock Institute of Medical Research, The University of Sydney, Sydney, Australia.
Zoe TerpeningThe University of Sydney, Faculty of Science, School of Psychology, Sydney, NSW, Australia.
Louisa NorrieSt Vincent's Hospital Older People's Mental Health Service, Darlinghurst, NSW, Australia.
Simon J G LewisThe University of Sydney, Faculty of Science, School of Psychology, Sydney, NSW, Australia.
Ian B HickieThe University of Sydney, Faculty of Science, School of Psychology, Sydney, NSW, Australia.
Sharon L NaismithThe University of Sydney, Faculty of Science, School of Psychology, Sydney, NSW, Australia.
University of Sydney · AUSt Vincent's Hospital · AUUNSW Sydney · AUWoolcock Institute of Medical Research · AU

Funding

NHMRC 632689
6 · The paper itself

Abstract

backgroundDepression is common in older people and is associated with underlying brain change increasing the risk of dementia. Sleep disturbance is frequently reported by those with lifetime depression, however whether circadian misalignment also exists is unclear. We aimed to examine circadian rhythms and sleep associations in older patients with and without lifetime depression.

methodsThirty-four older people meeting DSM-IV criteria for lifetime major depression (mean age = 63.9 years), and 30 healthy controls (mean age = 65.7 years) were recruited. Participants underwent 2-weeks of actigraphy followed by a 3-night protocol including dim light melatonin onset (DLMO) assessment and overnight polysomnography (PSG) for sleep architecture. DLMO and phase angle of entrainment were computed.

resultsCompared to controls, participants with depression had a significantly longer phase angle of entrainment (6.82 h ± 1.45 vs. 5.87 h ± 1.60, p = 0.02, Cohens-d = 0.62). A small to moderate yet non-significant difference in DLMO times, with earlier DLMO (34 ± 27 min) observed in depression (20:36 ± 1:48 vs. 21:10 ± 1:48, p = 0.22, Cohens-d = 0.32). Individuals with depression had longer sleep latency and latency to rapid eye movement sleep than controls (all p < 0.05).

conclusionCircadian advancement and alterations to the timing of sleep and REM onset are evident in older people with lifetime major depression, despite having only mild residual symptoms. Further research examining the prognostic significance of these changes is warranted as well as chronotherapeutic treatment studies.

Indexed as

Circadian RhythmActigraphyAgedCase-Control StudiesDepressionFemaleHumansMaleMelatoninMiddle AgedPolysomnographySleep LatencySleep, REMSleep Wake DisordersMelatoninCircadian misalignmentCircadian phaseDepressionOlder adultsSleep-wake disturbance

Identifiers

PMID32349697
PMCPMC7191686
OpenAlexW3020817963

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.