ArticleBMC genetics2020
Sex determination in the GIFT strain of tilapia is controlled by a locus in linkage group 23.
Article in BMC genetics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 48 citations in OpenAlex.
- Genomic Identification and Validation of Candidate Genes Associated with Alkalinity Tolerance in Exopalaemon carinicauda.Marine biotechnology (New York, N.Y.) · 2025Article
- Reconstruction of the X and Y haplotypes in the genetically improved Abbassa nile tilapia genome assembly.Scientific reports · 2025Article
- No evidence for sex chromosomes in natural populations of the cichlid fish Astatotilapia burtoni.G3 (Bethesda, Md.) · 2023Article
- Chromosome-level genome sequence of the Genetically Improved Farmed Tilapia (GIFT, Oreochromis niloticus) highlights regions of introgression with O. mossambicus.BMC genomics · 2022Article
- A genomic-based vision on the genetic diversity and key performance traits in selectively bred Arctic charr (Evolutionary applications · 2022Article
- First identification of two co-existing genome-wide significant sex quantitative trait loci (QTL) in red tilapia using integrative QTL mapping.Zoological research · 2022Article
- Whole genome resequencing data enables a targeted SNP panel for conservation and aquaculture ofAquaculture (Amsterdam, Netherlands) · 2022Article
- Polymorphism of Sex Determination Amongst Wild Populations Suggests its Rapid Turnover Within the Nile Tilapia Species.Frontiers in genetics · 2022Article
- A high-density linkage map and sex-linked markers for the Amazon Tambaqui Colossoma macropomum.BMC genomics · 2021Article
- Gene Variant ofInternational journal of molecular sciences · 2021Article
- Pomc Plays an Important Role in Sexual Size Dimorphism in Tilapia.Marine biotechnology (New York, N.Y.) · 2021Article
- Genotyping Strategies Using ddRAD Sequencing in Farmed Arctic Charr (Animals : an open access journal from MDPI · 2021Article
- Genomic Selection and Genome-wide Association Study for Feed-Efficiency Traits in a Farmed Nile Tilapia (Frontiers in genetics · 2021Article
- Genome-wide analysis clarifies the population genetic structure of wild gilthead sea bream (Sparus aurata).PloS one · 2021Article
- Article
- Local ancestry inference provides insight into Tilapia breeding programmes.Scientific reports · 2020Article
- Assessing the genetic diversity of farmed and wild Rufiji tilapia (Ecology and evolution · 2020Article
- Structure and Sequence of the Sex Determining Locus in Two Wild Populations of Nile Tilapia.Genes · 2020Article
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Authors and funding
8 authors at 4 institutions in 5 countries.
Funding
Abstract
backgroundTilapias (Family Cichlidae) are the second most important group of aquaculture species in the world. They have been the subject of much research on sex determination due to problems caused by early maturation in culture and their complex sex-determining systems. Different sex-determining loci (linkage group 1, 20 and 23) have been detected in various tilapia stocks. The 'genetically improved farmed tilapia' (GIFT) stock, founded from multiple Nile tilapia (Oreochromis niloticus) populations, with some likely to have been introgressed with O. mossambicus, is a key resource for tilapia aquaculture. The sex-determining mechanism in the GIFT stock was unknown, but potentially complicated due to its multiple origins.
resultsA bulk segregant analysis (BSA) version of double-digest restriction-site associated DNA sequencing (BSA-ddRADseq) was developed and used to detect and position sex-linked single nucleotide polymorphism (SNP) markers in 19 families from the GIFT strain breeding nucleus and two Stirling families as controls (a single XY locus had been previously mapped to LG1 in the latter). About 1500 SNPs per family were detected across the genome. Phenotypic sex in Stirling families showed strong association with LG1, whereas only SNPs located in LG23 showed clear association with sex in the majority of the GIFT families. No other genomic regions linked to sex determination were apparent. This region was validated using a series of LG23-specific DNA markers (five SNPs with highest association to sex from this study, the LG23 sex-associated microsatellite UNH898 and ARO172, and the recently isolated amhy marker for individual fish (n = 284).
conclusionsPerhaps surprisingly given its multiple origins, sex determination in the GIFT strain breeding nucleus was associated only with a locus in LG23. BSA-ddRADseq allowed cost-effective analysis of multiple families, strengthening this conclusion. This technique has potential to be applied to other complex traits. The sex-linked SNP markers identified will be useful for potential marker-assisted selection (MAS) to control sex-ratio in GIFT tilapia to suppress unwanted reproduction during growout.
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