ArticleBMC genomics2020
Draft genome sequences of Hirudo medicinalis and salivary transcriptome of three closely related medicinal leeches.
Article in BMC genomics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 56 citations in OpenAlex.
- Article
- Hirudins and ornatins in five species of the genus Placobdella (Annelida: Hirudinea: Glossiphoniidae).Protoplasma · 2026Article
- Feeding Strategy Shapes the Evolution of the Hyaluronidase Gene Family in Medicinal Leeches.Ecology and evolution · 2026Article
- Blood Relatives: Linking Evolutionary History and Conservation of Medicinal Leeches (Evolutionary applications · 2026Article
- Duplication of the Antistasin-Like Structure Resulted in a New Anticoagulant Protein in the Medicinal Leech.Biomolecules · 2026Article
- Effects of hirudotherapy on liver functions, lipid profile, and insulin sensitivity in rats with metabolic syndrome.BMC complementary medicine and therapies · 2026Article
- Comparative genomics suggests extensive antithrombotic gene expansion in Haemadipsa yanyuanensis.BMC genomics · 2025Article
- Production, Purification, and Characterization of a Novel Cysteine-Rich Anticoagulant from the Medicinal Leech and the Functional Role of Its C-Terminal Motif.Biomolecules · 2025Article
- Monomeric and Oligomeric Decorsins of the Asian Medicinal LeechInternational journal of molecular sciences · 2025Article
- Identification and Screening of Novel Antimicrobial Peptides from Medicinal Leech via Heterologous Expression inInternational journal of molecular sciences · 2025Article
- Chromosome-level genome assembly and anticoagulant protein annotation of the buffalo leech Hirudinaria bpling (Hirudinea: Hirudinidae).BMC genomics · 2025Article
- Evolutionary Convergence of Nutritional Symbionts in Ticks.Environmental microbiology reports · 2025Article
- Comparative genomics of three non-hematophagous leeches (Frontiers in genetics · 2025Article
- ERGA-BGE reference genome ofOpen research Europe · 2025Article
- Diversity of hirudin and hirudin-like factor genes in the North-African medicinal leech, Hirudo troctina.Parasitology research · 2024Article
- Acceleration of genome rearrangement in clitellate annelids.bioRxiv : the preprint server for biology · 2024Article
- Article
- Revisiting the Asian Buffalo Leech (Genes · 2023Article
- Dysbiosis of intestinal homeostasis contribute to Whitmania pigra edema disease.Microbial biotechnology · 2023Article
- Structural insights into thrombolytic activity of destabilase from medicinal leech.Scientific reports · 2023Article
Corrections and comments
- Erratum issued
Authors and funding
24 authors at 10 institutions in 2 countries.
Funding
Abstract
backgroundSalivary cell secretion (SCS) plays a critical role in blood feeding by medicinal leeches, making them of use for certain medical purposes even today.
resultsWe annotated the Hirudo medicinalis genome and performed RNA-seq on salivary cells isolated from three closely related leech species, H. medicinalis, Hirudo orientalis, and Hirudo verbana. Differential expression analysis verified by proteomics identified salivary cell-specific gene expression, many of which encode previously unknown salivary components. However, the genes encoding known anticoagulants have been found to be expressed not only in salivary cells. The function-related analysis of the unique salivary cell genes enabled an update of the concept of interactions between salivary proteins and components of haemostasis.
conclusionsHere we report a genome draft of Hirudo medicinalis and describe identification of novel salivary proteins and new homologs of genes encoding known anticoagulants in transcriptomes of three medicinal leech species. Our data provide new insights in genetics of blood-feeding lifestyle in leeches.
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