Evidence map›Paper›PMID 32349653›Full record

ReviewThe journal of headache and pain2020

From transformation to chronification of migraine: pathophysiological and clinical aspects.

M Torres-Ferrús, F Ursitti, A Alpuente, F Brunello, D Chiappino, T de Vries, S Di Marco, S Ferlisi, L Guerritore, N Gonzalez-Garcia and 13 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in The journal of headache and pain, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
77citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

77 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
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  17. Selective loss and transcriptional reprogramming of Nox4The journal of headache and pain · 2025
    Article
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17 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

M Torres-FerrúsHeadache and Craniofacial Pain Unit, Neurology Department, Hospital Universitari Vall d'Hebron, Headache and Neurological Pain Research Group, Vall d'Hebron Research Institute (VHIR), Departament de Medicina, Universitat Autònoma de Barcelona, Barcelona, Spain. marttorr@vhebron.net.
F UrsittiHeadache Center, Child Neurology Unit, Bambino Gesu' Children's Hospital, Rome, Italy.
A AlpuenteHeadache and Craniofacial Pain Unit, Neurology Department, Hospital Universitari Vall d'Hebron, Headache and Neurological Pain Research Group, Vall d'Hebron Research Institute (VHIR), Departament de Medicina, Universitat Autònoma de Barcelona, Barcelona, Spain.
F BrunelloJuvenile Headache Centre, Department of Woman's and Child's Health, University Hospital of Padua, Padua, Italy.
D ChiappinoDepartment of Internal medicine, Sant'Andrea Hospital, University of Rome, Sapienza, Italy.
T de VriesDivision of Vascular Medicine and Pharmacology, Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands.
S Di MarcoDepartment of Biomedicine Neuroscience and Advanced Diagnostics, Policlinico Paolo Giaccone Hospital, University of Palermo, Palermo, Italy.
S FerlisiDepartment of Biomedicine Neuroscience and Advanced Diagnostics, Policlinico Paolo Giaccone Hospital, University of Palermo, Palermo, Italy.
L GuerritoreDepartment of Internal medicine, Sant'Andrea Hospital, University of Rome, Sapienza, Italy.
N Gonzalez-GarciaHeadache and Craniofacial Pain Unit, Neurology Department, Hospital Universitario Clínico San Carlos, Madrid, Spain.
A Gonzalez-MartinezNeurology Department, Hospital Universitario de La Princesa & Instituto de Investigación Sanitaria de La Princesa, Universidad Autónoma de Madrid (UAM), Madrid, Spain.
D KhutorovDepartment of Clinical Neurology and Sleep Medicine, The Nikiforov Russian Center of Emergency and Radiation Medicine of EMERCOM of Russia, Saint-Petersburg, Russia.
M KritsilisGrevena General Hospital, Grevena, Greece.
A KyrouUniversity Hospital of Psychiatry and Psychotherapy, University of Bern, Switzerland University Hospital of Psychiatry, Bern, Switzerland.
T MakeevaHeadache Unit, Department of Neurology, Medical center "New Medical Technologies", Voronezh, Russia.
A Minguez-OlaondoDepartment of Neurology, Universitary Hospital of Donostia, San Sebastian, Spain.
L PilatiDepartment of Biomedicine Neuroscience and Advanced Diagnostics, Policlinico Paolo Giaccone Hospital, University of Palermo, Palermo, Italy.
A SerrienDepartment of Neurology, University Hospitals Leuven, Leuven, Belgium.
O TsurkalenkoDepartment of Neurology and Neurosurgery, State Institution "Dnipropetrovsk medical akademy MOH Ukraine", Dnipro, Ukraine.
D Van den AbbeeleDepartment of Neurology, Ghent University Hospital, Ghent, Belgium.
W S van HoogstratenDepartment of Neuroscience, Erasmus University Medical Centre, Rotterdam, The Netherlands.
C LamplHeadache Medical Center Linz, Ordensklinikum Linz Barmherzige Schwestern, Linz, Austria.
School of Advanced Studies of European Headache Federation (EHF-SAS)

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic migraine is a neurological disorder characterized by 15 or more headache days per month of which at least 8 days show typical migraine features. The process that describes the development from episodic migraine into chronic migraine is commonly referred to as migraine transformation or chronification. Ample studies have attempted to identify factors associated with migraine transformation from different perspectives. Understanding CM as a pathological brain state with trigeminovascular participation where biological changes occur, we have completed a comprehensive review on the clinical, epidemiological, genetic, molecular, structural, functional, physiological and preclinical evidence available.

Indexed as

Disease ProgressionChronic DiseaseEpigenesis, GeneticHumansMigraine DisordersNeuroimagingAnimal modelsBiomarkerChronic migraineGeneticsNeuroimagingNeurophysiologyPathophysiologyRisk factorsTransformation

Identifiers

PMID32349653
PMCPMC7189559

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.