Evidence map›Paper›PMID 32349537›Full record

ArticleExperimental biology and medicine (Maywood, N.J.)2020

Hepatitis B infection outcome is associated with novel human leukocyte antigen variants in Ghanaian cohort.

Kwesi Z Tandoh, Kwadwo A Kusi, Timothy N Archampong, Isaac Boamah, Osbourne Quaye

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental biology and medicine (Maywood, N.J.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Kwesi Z TandohWest African Centre for Cell Biology of Infectious Pathogens, College of Basic and Applied Sciences, University of Ghana, Legon LG54, Ghana.ORCID 0000-0002-1628-2845
Kwadwo A KusiWest African Centre for Cell Biology of Infectious Pathogens, College of Basic and Applied Sciences, University of Ghana, Legon LG54, Ghana.
Timothy N ArchampongDepartment of Medicine and Therapeutics, School of Medicine and Dentistry, University of Ghana, Accra 4236, Ghana.
Isaac BoamahDepartment of Microbiology, School of Medicine and Dentistry, University of Ghana, Accra Box 4236, Ghana.
Osbourne QuayeWest African Centre for Cell Biology of Infectious Pathogens, College of Basic and Applied Sciences, University of Ghana, Legon LG54, Ghana.ORCID 0000-0002-0621-876X
University of Ghana · GH

Funding

Wellcome Trust 107755/Z/15/Z
6 · The paper itself

Abstract

impact statementGenetic association studies can determine the effect size of gene loci on disease outcomes. In the arena of HBV infections, HLA alleles that associate with HBV outcomes can be used in clinical management decisions. This potential translational utility can shape the future management of HBV infections by identifying at-risk individuals and tailoring medical interventions accordingly. This precision medicine motif is currently only a nascent idea. However, it has stakes that may well override the current "wait and see" approach of clinical management of HBV infections. Here, we have identified HLA alleles associated with HBV outcome in a Ghanaian cohort. Our findings support the motif that HLA alleles associate with HBV outcome along geo-ethnic lines. This buttresses the need for further population pivoted studies. In the long term, our findings add to efforts towards the development of an HLA molecular-based algorithm for predicting HBV infection outcomes.

Indexed as

AdultAllelesFemaleGenetic Predisposition to DiseaseGenetic VariationGenotypeGhanaHepatitis B, ChronicHepatitis B virusHLA AntigensHumansMaleHLA Antigensassociationchronic hepatitis B infectiongeneticsHuman leukocyte antigenimmunologyvirology

Identifiers

PMID32349537
PMCPMC7273892
OpenAlexW3021597200

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.