Evidence map›Paper›PMID 32349449›Full record

SynthesisInternational journal of molecular sciences2020

Prevalence of Cytoplasmic Actin Mutations in Diffuse Large B-Cell Lymphoma and Multiple Myeloma: A Functional Assessment Based on Actin Three-Dimensional Structures.

Laura Witjes, Marleen Van Troys, Bruno Verhasselt, Christophe Ampe

Open access · goldAbstract readMeta-Analysis
In one paragraph

Synthesis in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.8field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Laura WitjesDepartment of Biomolecular Medicine, Ghent University, Albert Baertsoenkaai 3, B-9000 Ghent, Belgium.ORCID 0000-0001-5447-2087
Marleen Van TroysDepartment of Biomolecular Medicine, Ghent University, Albert Baertsoenkaai 3, B-9000 Ghent, Belgium.ORCID 0000-0003-4283-8103
Bruno VerhasseltDepartment of Diagnostic Sciences, Ghent University Hospital, Ghent University, Corneel Heymanslaan 10, B-9000 Ghent, Belgium.
Christophe AmpeDepartment of Biomolecular Medicine, Ghent University, Albert Baertsoenkaai 3, B-9000 Ghent, Belgium.ORCID 0000-0002-8554-3594
Ghent University · BEGhent University Hospital · BE

Funding

Faculty of Medicine and Health Sciences of Ghent University, Belgium AAP-bursery to L.W.
6 · The paper itself

Abstract

Mutations in actins have been linked to several developmental diseases. Their occurrence across different cancers has, however, not been investigated. Using the cBioPortal database we show that human actins are infrequently mutated in patient samples of various cancers types. Nevertheless, ranking these studies by mutational frequency suggest that some have a higher percentage of patients with

Indexed as

MutationActinsAllelesBiomarkers, TumorCytoplasmDatabases, GeneticGene AmplificationGene DeletionGenetic Association StudiesGenetic Predisposition to DiseaseHumansLymphoma, Large B-Cell, DiffuseModels, MolecularMultiple MyelomaMutation RateOrgan SpecificityActinsBiomarkers, TumorACTBACTG1actin mutationscBioPortalF-actinlymphoid cancermeta-analysis of patient datamyosinpatient cancer dataplasma cell myeloma

Identifiers

PMID32349449
PMCPMC7247664
OpenAlexW3018743188

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.