Trial reportInternational journal of environmental research and public health2020
Feasibility and Tolerability of a Culture-Based Virtual Reality (VR) Training Program in Patients with Mild Cognitive Impairment: A Randomized Controlled Pilot Study.
Trial report in International journal of environmental research and public health, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 13 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
41 citing papers in PubMed, 13 syntheses or guidelines pooled it, 99 citations in OpenAlex.
- Virtual Reality-Based Cognitive Training to Prevent Cognitive Decline in Older Adults With Mild Cognitive Impairment: A Systematic Review of Randomized Controlled Trials.Geriatrics & gerontology international · 2026Pooled it
- Immersive virtual reality for older adults with mild cognitive impairment, dementia, or cognitive frailty: a systematic review and narrative synthesis (2019-2025).BMC geriatrics · 2026Pooled it
- Effects of different interventions based on virtual reality on cognitive and motor function in elderly people with mild cognitive impairment or dementia: a systematic review and network meta-analysis.Frontiers in aging neuroscience · 2026Pooled it
- Bayesian network meta-analysis of the effects of different cognitive interventions on cognitive function in older adults with cognitive impairment.Frontiers in public health · 2026Pooled it
- Effect of virtual reality training on dual-task performance in older adults: a systematic review and meta-analysis.Journal of neuroengineering and rehabilitation · 2025Pooled it
- Virtual Reality Interventions for Older Adults With Mild Cognitive Impairment: Systematic Review and Meta-Analysis of Randomized Controlled Trials.Journal of medical Internet research · 2025Pooled it
- Effectiveness of VR-based cognitive training and games on cognitive rehabilitation in patients with MCI: a systematic review and meta-analysis.Frontiers in neurology · 2025Pooled it
- The effects of virtual reality-based interventions on cognitive function, depressive symptoms, and daily functioning in older adults with mild cognitive impairment: a systematic review and meta-analysis of randomized controlled trials.Frontiers in public health · 2025Pooled it
- Effects of fully immersive virtual reality training on cognitive function in patients with mild cognitive impairment: a systematic review and meta-analysis.Frontiers in human neuroscience · 2024Pooled it
- Effectiveness of computer-based interventions for community-dwelling people with cognitive decline: a systematic review with meta-analyses.BMC geriatrics · 2023Pooled it
- Fully Immersive Virtual Reality-Based Cognitive Remediation for Adults with Psychosocial Disabilities: A Systematic Scoping Review of Methods Intervention Gaps and Meta-Analysis of Published Effectiveness Studies.International journal of environmental research and public health · 2023Pooled it
- Ecological Effects of VR-Based Cognitive Training on ADL and IADL in MCI and AD patients: A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2022Pooled it
- Effect of virtual reality exercise on interventions for patients with Alzheimer's disease: A systematic review.Frontiers in psychiatry · 2022Pooled it
- The effect of virtual reality on the breastfeeding process: a randomized controlled study.Journal of perinatology : official journal of the California Perinatal Association · 2024Trial
- Outcomes reported in interventional studies for mild cognitive impairment: a scoping umbrella review to inform core outcome set development.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Navigating Aging with Technology: A Scoping Review of Digital Interventions Addressing Intrinsic Capacity Decline in Older Adults.Healthcare (Basel, Switzerland) · 2026Review
- Effectiveness of virtual reality-based nature interventions in promoting mental health outcomes among older adults with cognitive impairment: a systematic review and meta-regression analysis.Australian journal of psychology · 2026Review
- Digital Health Technologies Applied in Patients With Early Cognitive Change: Scoping Review.Journal of medical Internet research · 2025Article
- Virtual Reality-Based Cognitive and Physical Interventions in Cognitive Impairment: A Network Meta-Analysis of Immersion Level Effects.Behavioral sciences (Basel, Switzerland) · 2025Review
- Examining Technology Perspectives of Older Adults With Mild Cognitive Impairment: Scoping Review.JMIR aging · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The present study examined whether a culture-based virtual reality (VR) training program is feasible and tolerable for patients with amnestic mild cognitive impairment (aMCI), and whether it could improve cognitive function in these patients. Twenty-one outpatients with aMCI were randomized to either the VR-based training group or the control group in a 1∶1 ratio. The VR-based training group participated in training for 30 min/day, two days/week, for three months (24 times). The VR-based program was designed based on Korean traditional culture and used attention, processing speed, executive function and memory conditions to stimulate cognitive function. The adherence to the culture-based VR training program was 91.55% ± 6.41% in the VR group. The only adverse events observed in the VR group were dizziness (4.2%) and fatigue (8.3%). Analysis revealed that the VR-based training group exhibited no significant differences following the three-month VR program in Korean Mini-Mental State Examination (K-MMSE) scores, working memory functions such as performance on the digit span test, or in Stroop test performance and word fluency. We conclude that although the 12-week culture-based VR training program did not improve cognitive function, our findings revealed that the culture-based VR training program was feasible and tolerable for participants with aMCI.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.