ArticleBrain sciences2020
Site-Specific Effects of Online rTMS during a Working Memory Task in Healthy Older Adults.
Article in Brain sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- Outcome measures for electric field modeling in tES and TMS: A systematic review and large-scale modeling study.NeuroImage · 2023Pooled it
- Neural oscillatory responses to performance monitoring differ between high- and low-impulsive individuals, but are unaffected by TMS.Human brain mapping · 2021Trial
- Feasibility of Integrating Real-Time fMRI Neurofeedback with rTMS: Study Design, Preliminary Results, and Technical Challenges.Aperture neuro · 2026Article
- Lateral Cerebellar Theta Burst Stimulation Can Modulate Default Mode Network Connectivity in Autistic Adults.Cerebellum (London, England) · 2025Article
- Efficient prospective electric field-informed localization of motor cortical targets of transcranial magnetic stimulation.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Real-time computation of brain E-field for enhanced transcranial magnetic stimulation neuronavigation and optimization.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Individualised Transcranial Magnetic Stimulation Targeting of the Left Dorsolateral Prefrontal Cortex for Enhancing Cognition: A Randomised Controlled Trial.Brain sciences · 2024Article
- Electric Field Modeling in Personalizing Transcranial Magnetic Stimulation Interventions.Biological psychiatry · 2024Review
- Repetitive transcranial magnetic stimulation (rTMS) as a tool for cognitive enhancement in healthy adults: a review study.Medical & biological engineering & computing · 2024Review
- Fast computational E-field dosimetry for transcranial magnetic stimulation using adaptive cross approximation and auxiliary dipole method (ACA-ADM).NeuroImage · 2023Article
- Resting-State Functional Connectivity Differences Following Experimental Manipulation of the Orbitofrontal Cortex in Two Directions via Theta-Burst Stimulation.Clinical psychological science : a journal of the Association for Psychological Science · 2023Article
- Transcranial magnetic stimulation of the brain: What is stimulated? - A consensus and critical position paper.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2022Review
- TAP: targeting and analysis pipeline for optimization and verification of coil placement in transcranial magnetic stimulation.Journal of neural engineering · 2022Article
- Dosing Transcranial Magnetic Stimulation of the Primary Motor and Dorsolateral Prefrontal Cortices With Multi-Scale Modeling.Frontiers in neuroscience · 2022Article
- Network-based rTMS to modulate working memory: The difficult choice of effective parameters for online interventions.Brain and behavior · 2021Article
- Stimulating Memory: Reviewing Interventions Using Repetitive Transcranial Magnetic Stimulation to Enhance or Restore Memory Abilities.Brain sciences · 2021Review
- Effect of Experimental Manipulation of the Orbitofrontal Cortex on Short-Term Markers of Compulsive Behavior: A Theta Burst Stimulation Study.The American journal of psychiatry · 2021Article
- Fast computational optimization of TMS coil placement for individualized electric field targeting.NeuroImage · 2021Article
- Working Memory and Cross-Frequency Coupling of Neuronal Oscillations.Frontiers in psychology · 2021Review
- Transcranial Magnetic Stimulation in Psychiatry: Is There a Need for Electric Field Standardization?Frontiers in human neuroscience · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 2 institutions in 1 country.
Funding
Abstract
The process of manipulating information within working memory is central to many cognitive functions, but also declines rapidly in old age. Improving this process could markedly enhance the health-span in older adults. The current pre-registered, randomized and placebo-controlled study tested the potential of online repetitive transcranial magnetic stimulation (rTMS) applied at 5 Hz over the left lateral parietal cortex to enhance working memory manipulation in healthy elderly adults. rTMS was applied, while participants performed a delayed-response alphabetization task with two individually titrated levels of difficulty. Coil placement and stimulation amplitude were calculated from fMRI activation maps combined with electric field modeling on an individual-subject basis in order to standardize dosing at the targeted cortical location. Contrary to the a priori hypothesis, active rTMS significantly decreased accuracy relative to sham, and only in the hardest difficulty level. When compared to the results from our previous study, in which rTMS was applied over the left prefrontal cortex, we found equivalent effect sizes but opposite directionality suggesting a site-specific effect of rTMS. These results demonstrate engagement of cortical working memory processing using a novel TMS targeting approach, while also providing prescriptions for future studies seeking to enhance memory through rTMS.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.