Evidence map›Paper›PMID 32349121›Full record

ArticleNature2020

Massively multiplexed nucleic acid detection with Cas13.

Cheri M Ackerman, Cameron Myhrvold, Sri Gowtham Thakku, Catherine A Freije, Hayden C Metsky, David K Yang, Simon H Ye, Chloe K Boehm, Tinna-Sólveig F Kosoko-Thoroddsen, Jared Kehe and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 361 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
361citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

361 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. CRISPR/Cas Systems: Biological Basis and Genome Editing Applications.Methods in molecular biology (Clifton, N.J.) · 2027
    Review
  6. Review
  7. Article
  8. Article
  9. Attomolar Detection of HIV-1 With Label-Free RCA-rCRISPR on Smartphone.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  10. Article
  11. Article
  12. Review
  13. Review
  14. Article
  15. Article
  16. Review
  17. Article
  18. Machine Learning for CRISPR-Based Diagnostics.International journal of molecular sciences · 2026
    Review
  19. Article
  20. Review

301 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors.

Cheri M Ackerman *Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA.
Cameron Myhrvold *Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA. cmyhrvol@broadinstitute.org.ORCID http://orcid.org/0000-0002-8971-184X
Sri Gowtham ThakkuBroad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA.
Catherine A FreijeBroad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-1939-3102
Hayden C MetskyBroad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-8871-2349
David K YangBroad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-9972-3035
Simon H YeBroad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA.
Chloe K BoehmBroad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA.
Tinna-Sólveig F Kosoko-ThoroddsenBroad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA.
Jared KeheBroad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA.
Tien G NguyenBroad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA.
Amber CarterBroad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA.
Anthony KulesaBroad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA.
John R BarnesInfluenza Division, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Vivien G DuganInfluenza Division, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Deborah T HungBroad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA.
Paul C BlaineyBroad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA. pblainey@broadinstitute.org.ORCID http://orcid.org/0000-0002-4889-8783
Pardis C SabetiBroad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA.

Funding

Graduate Training in Computational and Systems BiologyT32GM087237 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI BURGE, CHRISTOPHER B · 2009 to 2023
$4.6M
Discovery of compounds and genes that regulate cancer's epigenome, using combinatorial screening in a nanodrop-microwell platformF32CA236425 · NCI · BROAD INSTITUTE, INC. · PI ACKERMAN, CHERI MARIE · 2019 to 2020
$91k
Howard Hughes Medical InstituteNCI NIH HHS F32 CA236425
6 · The paper itself

Abstract

The great majority of globally circulating pathogens go undetected, undermining patient care and hindering outbreak preparedness and response. To enable routine surveillance and comprehensive diagnostic applications, there is a need for detection technologies that can scale to test many samples

Indexed as

AnimalsBetacoronavirusCRISPR-Associated ProteinsCRISPR-Cas SystemsDrug Resistance, ViralGenome, ViralHIVHumansInfluenza A virusMicrofluidic Analytical TechniquesRNA, Guide, CRISPR-Cas SystemsSARS-CoV-2Sensitivity and SpecificityVirus DiseasesCRISPR-Associated ProteinsRNA, Guide, CRISPR-Cas Systems

Identifiers

PMID32349121
PMCPMC7332423

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.