Evidence map›Paper›PMID 32349088›Full record

ArticleClinical nuclear medicine2020

Rosai-Dorfman Disease-Utility of 18F-FDG PET/CT for Initial Evaluation and Follow-up.

Sonia Mahajan, Reiko Nakajima, Mariko Yabe, Ahmet Dogan, Gary A Ulaner, Joachim Yahalom, Ariela Noy, Eli L Diamond, Heiko Schöder

Abstract read
In one paragraph

Article in Clinical nuclear medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Diagnostic impact of 18F-FDG PET/MRI over PET/CT in histiocytoses: a prospective comparative study.European journal of nuclear medicine and molecular imaging · 2026
    Article
  2. Article
  3. Review
  4. Review
  5. Sinonasal presentations of Rosai-Dorfman disease: a scoping review.The Journal of laryngology and otology · 2025
    Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Extranodal Rosai-Dorfman disease involving pulmonary artery detected byEuropean journal of nuclear medicine and molecular imaging · 2023
    Article
  12. The value ofOrphanet journal of rare diseases · 2023
    Review
  13. Article
  14. The Impact of PET/CT on Paediatric Oncology.Diagnostics (Basel, Switzerland) · 2023
    Review
  15. Article
  16. Potential role ofAsia Oceania journal of nuclear medicine & biology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Sonia MahajanFrom the Department of Radiology, NYU School of Medicine.
Reiko NakajimaDepartments of Radiology.
Mariko YabePathology.
Ahmet DoganPathology.
Gary A UlanerDepartments of Radiology.
Joachim YahalomRadiation Oncology.
Ariela NoyMedicine.
Eli L DiamondNeurology, Memorial Sloan Kettering Cancer Center, New York, NY.
Heiko SchöderDepartments of Radiology.

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

backgroundThe role of imaging in the management of Rosai-Dorfman disease (RDD), a rare non-Langerhans cell histiocytosis, is not clearly defined. We present an analysis of FDG PET/CT findings obtained for initial disease characterization, follow-up evaluation, and treatment planning for this disease.

methodsFrom an institutional pathology database (2001-2018), we identified RDD patients who underwent FDG PET/CT scans either as part of clinical care or when done as part of clinical trials. For all scans, sites of abnormal FDG uptake were assessed, and SUVmax was measured. Comparison of PET/CT findings was made with anatomic (CT/MRI-based) imaging, where available. Instances of changing treatment based on PET/CT were recorded.

resultsWe reviewed 109 FDG PET/CT scans in 27 patients with RDD. Five of 27 patients had only nodal/cutaneous disease, whereas 22 patients had extranodal disease, most commonly in bone (n = 9) and central nervous system (n = 7). PET/CT identified sites of active disease in 24 of 27 patients. All identified bone and extraskeletal lesions, except for a brain lesion in 1 patient, were FDG-avid. In 6 of 20 patients (30%) with available prior CT or MRI, PET/CT demonstrated additional RDD lesions (bones: n = 5, pleura: n = 1) that were not apparent on anatomic imaging; 3 of these lesions were outside the CT field of view, and 3 were not recognized on CT. Overall, 13 of 109 PET/CT scans led to a change in management, affecting 41% (11/27) of patients.

conclusionFDG PET/CT was valuable in defining disease extent and optimizing treatment strategy in patients with RDD.

Indexed as

Fluorodeoxyglucose F18Positron Emission Tomography Computed TomographyAdultFemaleFollow-Up StudiesHistiocytosis, SinusHumansMaleMiddle AgedFluorodeoxyglucose F18

Identifiers

PMID32349088
PMCPMC8177955

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.