ArticleCell host & microbe2020
A Genomic Toolkit for the Mechanistic Dissection of Intractable Human Gut Bacteria.
Article in Cell host & microbe, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
46 citing papers in PubMed.
- Enterolignan Production in a Flaxseed Intervention Study in Postmenopausal US Women of African Ancestry and European Ancestry.Nutrients · 2021Trial
- Eggerthella lenta: metabolism, pathogenesis and therapeutic implications.Nature reviews. Microbiology · 2026Review
- Anaerobic riboflavin degradation by human gutJournal of bacteriology · 2026Article
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- A widespread gut bacterial lineage distinguished by redox metabolism and phage defense.bioRxiv : the preprint server for biology · 2026Article
- Female-enrichedbioRxiv : the preprint server for biology · 2026Article
- Anaerobic riboflavin degradation by human gutbioRxiv : the preprint server for biology · 2026Article
- Understanding the human gut microbiome: from composition to disease association.Frontiers in microbiomes · 2026Review
- Urease in acetogenicGut microbes · 2025Article
- Members of Lachnospiraceae produce valerate and caproate in response to short-chain fatty acids.Microbiome · 2025Article
- StrainR2 accurately deconvolutes strain-level abundances in synthetic microbial communities.Bioinformatics (Oxford, England) · 2025Article
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- Microbiome Single Cell Atlases Generated with a Commercial Instrument.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- A designed synthetic microbiota provides insight to community function in Clostridioides difficile resistance.Cell host & microbe · 2025Article
- Iron-sulfur cluster-dependent enzymes and molybdenum-dependent reductases in the anaerobic metabolism of human gut microbes.Metallomics : integrated biometal science · 2024Review
- Article
- Simvastatin induces human gut bacterial cell surface genes.Molecular microbiology · 2024Article
- Emerging tools and best practices for studying gut microbial community metabolism.Nature metabolism · 2024Review
- Human gut Actinobacteria boost drug absorption by secreting P-glycoprotein ATPase inhibitors.iScience · 2024Article
Corrections and comments
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Authors and funding
17 authors.
Funding
Abstract
Despite the remarkable microbial diversity found within humans, our ability to link genes to phenotypes is based upon a handful of model microorganisms. We report a comparative genomics platform for Eggerthella lenta and other Coriobacteriia, a neglected taxon broadly relevant to human health and disease. We uncover extensive genetic and metabolic diversity and validate a tool for mapping phenotypes to genes and sequence variants. We also present a tool for the quantification of strains from metagenomic sequencing data, enabling the identification of genes that predict bacterial fitness. Competitive growth is reproducible under laboratory conditions and attributable to intrinsic growth rates and resource utilization. Unique signatures of in vivo competition in gnotobiotic mice include an adhesin enriched in poor colonizers. Together, these computational and experimental resources represent a strong foundation for the continued mechanistic dissection of the Coriobacteriia and a template that can be applied to study other genetically intractable taxa.
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Registered trials
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