Evidence map›Paper›PMID 32348717›Full record

ArticleNeuron2020

Voltage-Gated Intrinsic Conductances Shape the Input-Output Relationship of Cortical Neurons in Behaving Primate V1.

Baowang Li, Brandy N Routh, Daniel Johnston, Eyal Seidemann, Nicholas J Priebe

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuron, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Article
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  4. The fluctuation-based regime of thalamocortical circuitry.bioRxiv : the preprint server for biology · 2025
    Article
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  13. Review
  14. A recurrent circuit implements normalization, simulating the dynamics of V1 activity.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Baowang LiCenter for Perceptual Systems, The University of Texas at Austin, 2415 Speedway, Austin, TX 78712, USA; Center for Learning and Memory, The University of Texas at Austin, 2415 Speedway, Austin, TX 78712, USA; Department of Neuroscience, The University of Texas at Austin, 2415 Speedway, Austin, TX 78712, USA; Department of Psychology, The University of Texas at Austin, 2415 Speedway, Austin, TX 78712, USA.
Brandy N RouthCenter for Learning and Memory, The University of Texas at Austin, 2415 Speedway, Austin, TX 78712, USA; Department of Neuroscience, The University of Texas at Austin, 2415 Speedway, Austin, TX 78712, USA.
Daniel JohnstonCenter for Learning and Memory, The University of Texas at Austin, 2415 Speedway, Austin, TX 78712, USA; Department of Neuroscience, The University of Texas at Austin, 2415 Speedway, Austin, TX 78712, USA.
Eyal SeidemannCenter for Perceptual Systems, The University of Texas at Austin, 2415 Speedway, Austin, TX 78712, USA; Department of Neuroscience, The University of Texas at Austin, 2415 Speedway, Austin, TX 78712, USA; Department of Psychology, The University of Texas at Austin, 2415 Speedway, Austin, TX 78712, USA. Electronic address: eyal@austin.utexas.edu.
Nicholas J PriebeCenter for Learning and Memory, The University of Texas at Austin, 2415 Speedway, Austin, TX 78712, USA; Department of Neuroscience, The University of Texas at Austin, 2415 Speedway, Austin, TX 78712, USA. Electronic address: nicholas@mail.utexas.edu.

Funding

Linking Neural Population Activity and Visual PerceptionR01EY016454 · NEI · UNIVERSITY OF TEXAS AUSTIN · PI SEIDEMANN, EYAL J · 2005 to 2024
$6.6M
Cortical mechanisms mediating visual function and behaviorR01EY024071 · NEI · UNIVERSITY OF TEXAS AT AUSTIN · PI PRIEBE, NICHOLAS J, SEIDEMANN, EYAL J · 2014 to 2025
$4.1M
NEI NIH HHS R01 EY016454NEI NIH HHS R01 EY024071
6 · The paper itself

Abstract

Neurons are input-output (I/O) devices-they receive synaptic inputs from other neurons, integrate those inputs with their intrinsic properties, and generate action potentials as outputs. To understand this fundamental process, we studied the interaction between synaptic inputs and intrinsic properties using whole-cell recordings from V1 neurons of awake, fixating macaque monkeys. Our measurements during spontaneous activity and visual stimulation reveal an intrinsic voltage-gated conductance that profoundly alters the integrative properties and visual responses of cortical neurons. This voltage-gated conductance increases neuronal gain and selectivity with subthreshold depolarization and linearizes the relationship between synaptic input and neural output. This intrinsic conductance is found in layer 2/3 V1 neurons of awake macaques, anesthetized mice, and acute brain slices. These results demonstrate that intrinsic conductances play an essential role in shaping the I/O relationship of cortical neurons and must be taken into account in future models of cortical computations.

Indexed as

Models, NeurologicalAction PotentialsAnimalsBehavior, AnimalMacaca mulattaMiceMice, Inbred C57BLNeuronsVisual Cortexintracellular recordingintrinsic conductanceprimary visual cortexresponse selectivity

Identifiers

PMID32348717
PMCPMC9084915

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.