ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2020
Muscle metaboreflex-induced increases in effective arterial elastance: effect of heart failure.
Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 12 citations in OpenAlex.
- Exercise, Prostaglandin ECells · 2026Review
- Mechanisms mediating muscle metaboreflex control of cardiac output during exercise: Impaired regulation in heart failure.Experimental physiology · 2025Review
- Altered Autonomic Function in Metabolic Syndrome: Interactive Effects of Multiple Components.Journal of clinical medicine · 2024Review
- Muscle metaboreflex stimulates the cardiac sympathetic afferent reflex causing positive feedback amplification of sympathetic activity: effect of heart failure.American journal of physiology. Regulatory, integrative and comparative physiology · 2024Article
- Augmented sympathoexcitation slows postexercise heart rate recovery.Journal of applied physiology (Bethesda, Md. : 1985) · 2023Article
- Blood flow restriction training activates the muscle metaboreflex during low-intensity sustained exercise.Journal of applied physiology (Bethesda, Md. : 1985) · 2023Article
- A cross-species validation of single-beat metrics of cardiac contractility.The Journal of physiology · 2022Article
- Ventricular-Vascular Uncoupling in Heart Failure: Effects of Arterial Baroreflex-Induced Sympathoexcitation at Rest and During Exercise.Frontiers in physiology · 2022Article
- Arterial Baroreflex Inhibits Muscle Metaboreflex Induced Increases in Effective Arterial Elastance: Implications for Ventricular-Vascular Coupling.Frontiers in physiology · 2022Article
- Chronic ablation of TRPV1-sensitive skeletal muscle afferents attenuates the muscle metaboreflex.American journal of physiology. Regulatory, integrative and comparative physiology · 2021Article
- Ventricular contraction and relaxation rates during muscle metaboreflex activation in heart failure: are they coupled?Experimental physiology · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Dynamic exercise elicits robust increases in sympathetic activity in part due to muscle metaboreflex activation (MMA), a pressor response triggered by activation of skeletal muscle afferents. MMA during dynamic exercise increases arterial pressure by increasing cardiac output via increases in heart rate, ventricular contractility, and central blood volume mobilization. In heart failure, ventricular function is compromised, and MMA elicits peripheral vasoconstriction. Ventricular-vascular coupling reflects the efficiency of energy transfer from the left ventricle to the systemic circulation and is calculated as the ratio of effective arterial elastance (
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.