Evidence map›Paper›PMID 32348679›Full record

ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2020

Circadian clock genes and respiratory neuroplasticity genes oscillate in the phrenic motor system.

Mia N Kelly, Danelle N Smith, Michael D Sunshine, Ashley Ross, Xiping Zhang, Michelle L Gumz, Karyn A Esser, Gordon S Mitchell

Open access · bronzeAbstract read
In one paragraph

Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.9field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 30 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Characterization of Ventilatory Drive in Community-Dwelling Adults with Chronic Spinal Cord Injury.Archives of rehabilitation research and clinical translation · 2025
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Melatonin signalling in Schwann cells during neuroregeneration.Frontiers in cell and developmental biology · 2022
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Mia N KellyCenter for Respiratory Research and Rehabilitation, University of Florida, Gainesville, Florida.ORCID 0000-0002-8677-4327
Danelle N SmithCenter for Respiratory Research and Rehabilitation, University of Florida, Gainesville, Florida.
Michael D SunshineCenter for Respiratory Research and Rehabilitation, University of Florida, Gainesville, Florida.
Ashley RossCenter for Respiratory Research and Rehabilitation, University of Florida, Gainesville, Florida.
Xiping ZhangDepartment of Physiology and Functional Genomics, University of Florida, Gainesville, Florida.
Michelle L GumzDepartment of Medicine, University of Florida, Gainesville, Florida.
Karyn A EsserDepartment of Physiology and Functional Genomics, University of Florida, Gainesville, Florida.ORCID 0000-0002-5791-1441
Gordon S MitchellCenter for Respiratory Research and Rehabilitation, University of Florida, Gainesville, Florida.
University of Florida · US

Funding

University of Florida Older Americans Independence Center (OAIC)P30AG028740 · NIA · UNIVERSITY OF FLORIDA · PI Stephen D Anton · 2007 to 2026
$22.8M
Breathing Research and Therapeutics (BREATHE)T32HL134621 · NHLBI · UNIVERSITY OF FLORIDA · PI Gordon S. Mitchell · 2017 to 2026
$3.4M
Regulation of Intermittent Hypoxia-Induced Respiratory Motor PlasticityR01HL148030 · NHLBI · UNIVERSITY OF FLORIDA · PI MITCHELL, GORDON S. · 2019 to 2022
$2.4M
Muscle clock disruption accelerates the onset and progression of neurodegenerationR01AR066082 · NIAMS · UNIVERSITY OF KENTUCKY · PI ESSER, KARYN A · 2014 to 2018
$2.0M
Respiratory Plasticity and Spinal Cord InjuryR01HL069064 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI MITCHELL, GORDON S. · 2014 to 2017
$1.5M
Per1 and the kidney clock in hypertensionR01DK109570 · NIDDK · UNIVERSITY OF FLORIDA · PI GUMZ, MICHELLE L · 2017 to 2021
$1.5M
A new method of spinal stimulation TO activate the diaphragmF31HL145831 · NHLBI · UNIVERSITY OF FLORIDA · PI SUNSHINE, MICHAEL · 2019 to 2020
$74k
HHS | National Institutes of Health (NIH) 1R01DK109570-01A1NHLBI NIH HHS F31 HL145831NHLBI NIH HHS R01 HL069064NHLBI NIH HHS R01 HL148030NHLBI NIH HHS T32 HL134621NIAMS NIH HHS R01 AR066082NIA NIH HHS P30 AG028740NIDDK NIH HHS R01 DK109570
6 · The paper itself

Abstract

Circadian rhythms are endogenous and entrainable daily patterns of physiology and behavior. Molecular mechanisms underlie circadian rhythms, characterized by an ~24-h pattern of gene expression of core clock genes. Although it has long been known that breathing exhibits circadian rhythms, little is known concerning clock gene expression in any element of the neuromuscular system controlling breathing. Furthermore, we know little concerning gene expression necessary for specific respiratory functions, such as phrenic motor plasticity. Thus, we tested the hypotheses that transcripts for clock genes (

Indexed as

AnimalsARNTL Transcription FactorsBrain-Derived Neurotrophic FactorCircadian ClocksCircadian RhythmCLOCK ProteinsGene ExpressionMaleMotor NeuronsNeuronal PlasticityPeriod Circadian ProteinsPhrenic NerveRatsRats, Sprague-DawleySpinal CordARNTL Transcription FactorsBrain-Derived Neurotrophic FactorCLOCK ProteinsPer1 protein, ratPer2 protein, ratPeriod Circadian ProteinsBDNFcircadian rhythmcontrol of breathingmotor neuronplasticityserotoninspinal cord

Identifiers

PMID32348679
PMCPMC7311680
OpenAlexW3018182199

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.