Evidence map›Paper›PMID 32348677›Full record

ArticleAmerican journal of physiology. Lung cellular and molecular physiology2020

Normal murine respiratory tract has its mucus concentrated in clouds based on the Muc5b mucin.

Dalia Fakih, Ana M Rodriguez-Piñeiro, Sergio Trillo-Muyo, Christopher M Evans, Anna Ermund, Gunnar C Hansson

Abstract read
In one paragraph

Article in American journal of physiology. Lung cellular and molecular physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
  2. Article
  3. Airway secretory cells contain both a perinuclear Golgi ribbon and dispersed Golgi satellites.American journal of respiratory cell and molecular biology · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Role of mucociliary clearance system in respiratory diseases.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2023
    Article
  12. Mucins MUC5AC and MUC5B Are Variably Packaged in the Same and in Separate Secretory Granules.American journal of respiratory and critical care medicine · 2022
    Article
  13. Chloride channel accessory 1 gene deficiency causes selective loss of mucus production in a new pig model.American journal of physiology. Lung cellular and molecular physiology · 2022
    Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Dalia FakihDepartment of Medical Biochemistry, University of Gothenburg, Gothenburg, Sweden.
Ana M Rodriguez-PiñeiroDepartment of Medical Biochemistry, University of Gothenburg, Gothenburg, Sweden.
Sergio Trillo-MuyoDepartment of Medical Biochemistry, University of Gothenburg, Gothenburg, Sweden.
Christopher M EvansUniversity of Colorado Denver School of Medicine, Aurora, Colorado.
Anna ErmundDepartment of Medical Biochemistry, University of Gothenburg, Gothenburg, Sweden.
Gunnar C HanssonDepartment of Medical Biochemistry, University of Gothenburg, Gothenburg, Sweden.

Funding

Role of Mucin in Lung Homeostasis and PathophysiologyR01HL080396 · NHLBI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Christopher M Evans · 2009 to 2026
$8.6M
Lung Macrophage Programming in Acute Lung InjuryR35HL140039 · NHLBI · NATIONAL JEWISH HEALTH · PI JANSSEN, WILLIAM · 2018 to 2024
$6.4M
Mechanisms of lung macrophage programming by MUC5B during health and diseaseR01HL130938 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI EVANS, CHRISTOPHER M · 2016 to 2025
$5.2M
The MUC2 Mucus Gel as an Innate Immune Mechanism that Inhibits InflammationU01AI095473 · NIAID · GOTEBORG UNIVERSITY · PI HANSSON, GUNNAR C., JOHANSSON, MALIN E.V. · 2011 to 2020
$2.6M
HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) U01AI095473NHLBI NIH HHS R01 HL080396NHLBI NIH HHS R01 HL130938NHLBI NIH HHS R35 HL140039NIAID NIH HHS U01 AI095473
6 · The paper itself

Abstract

The organization of the normal airway mucus system differs in small experimental animals from that in humans and large mammals. To address normal murine airway mucociliary clearance, Alcian blue-stained mucus transport was measured ex vivo on tracheal tissues of naïve C57BL/6,

Indexed as

AnimalsBiological TransportFluorescenceGoblet CellsMice, Inbred C57BLMucin 5ACMucin-5BMucous MembraneMucusRespiratory SystemTracheaMucin 5ACMucin-5Bairwaybronchimucus bundlessubmucosal glandstrachea

Identifiers

PMID32348677
PMCPMC7347266

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.