ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2020
Drivers of Frailty from Adulthood into Old Age: Results from a 27-Year Longitudinal Population-Based Study in Sweden.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 45 citations in OpenAlex.
- Early Adoption of Digital Devices and Change in Loneliness Over 10 Years Among Late Middle-Aged and Older Adults: Longitudinal Cohort Study.JMIR formative research · 2026Article
- Association between body mass index and frailty for middle-aged and older adults in Japan: a cross-sectional study of the Osaka health disparity solution program.BMC public health · 2026Article
- Marital and living status and biological ageing trajectories: a longitudinal cohort study with a 20-year follow-up.Biogerontology · 2025Article
- Secular trends in frailty among community-dwelling 75-95-year-old cohorts over three decades in Helsinki, Finland.Age and ageing · 2024Article
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- Midlife cumulative deficit frailty predicts Alzheimer's disease-related plasma biomarkers in older adults.Age and ageing · 2024Article
- Comparison of two different frailty scales in the longitudinal Swedish Adoption/Twin Study of Aging (SATSA).Scandinavian journal of public health · 2023Article
- Longitudinal associations between use of antihypertensive, antidiabetic, and lipid-lowering medications and biological aging.GeroScience · 2023Article
- Associations Between Frailty and the Increased Risk of Adverse Outcomes Among 38,950 UK Biobank Participants With Prediabetes: Prospective Cohort Study.JMIR public health and surveillance · 2023Article
- Genetic and Environmental Influences on Longitudinal Frailty Trajectories From Adulthood into Old Age.The journals of gerontology. Series A, Biological sciences and medical sciences · 2023Article
- Article
- Childhood experiences and frailty trajectory among middle-aged and older adults in China.European journal of ageing · 2022Article
- Body mass index and Mini Nutritional Assessment-Short Form as predictors of in-geriatric hospital mortality in older adults with COVID-19.Clinical nutrition (Edinburgh, Scotland) · 2022Article
- Trajectories, Transitions, and Trends in Frailty among Older Adults: A Review.Annals of geriatric medicine and research · 2022Article
- Frailty Risk Prediction Model among Older Adults: A Chinese Nation-Wide Cross-Sectional Study.International journal of environmental research and public health · 2022Article
- Frailty trajectories in three longitudinal studies of aging: Is the level or the rate of change more predictive of mortality?Age and ageing · 2021Article
- Frailty and the risk of dementia: is the association explained by shared environmental and genetic factors?BMC medicine · 2021Article
- A genome-wide association study of the frailty index highlights brain pathways in ageing.Aging cell · 2021Article
- The degree of frailty as a translational measure of health in aging.Nature aging · 2021Review
- Article
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundFrailty is a strong predictor of adverse outcomes. However, longitudinal drivers of frailty are not well understood. This study aimed at investigating the longitudinal trajectories of a frailty index (FI) from adulthood to late life and identifying the factors associated with the level and rate of change in FI.
methodsAn age-based latent growth curve analysis was performed in the Swedish Adoption/Twin Study of Aging (N = 1,842; aged 29-102 years) using data from up to 15 measurement waves across 27 years. A 42-item FI was used to measure frailty at each wave.
resultsA bilinear, two-slope model with a turning point at age 65 best described the age-related change in FI, showing that the increase in frailty was more than twice as fast after age 65. Underweight, obesity, female sex, overweight, being separated from one's co-twin during childhood, smoking, poor social support, and low physical activity were associated with a higher FI at age 65, with underweight having the largest effect size. When tested as time-varying covariates, underweight and higher social support were associated with a steeper increase in FI before age 65, whereas overweight and obesity were associated with less steep increase in FI after age 65.
conclusionsFactors associated with the level and rate of change in frailty are largely actionable and could provide targets for intervention. As deviations from normal weight showed the strongest associations with frailty, future public health programs could benefit from monitoring of individuals with abnormal BMI, especially those who are underweight.
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