ArticlePloS one2020
Total daily physical activity, brain pathologies, and parkinsonism in older adults.
Article in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 9 citations in OpenAlex.
- The time course of motor and cognitive decline in older adults and their associations with brain pathologies: a multicohort study.The lancet. Healthy longevity · 2024Article
- Correlated decline of cognitive and motor phenotypes and ADRD pathologies in old age.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2023Article
- Correlates of Person-Specific Rates of Change in Sensor-Derived Physical Activity Metrics of Daily Living in the Rush Memory and Aging Project.Sensors (Basel, Switzerland) · 2023Article
- Neurodegenerative and Cerebrovascular Brain Pathologies Are Differentially Associated With Declining Grip Strength and Gait In Older Adults.The journals of gerontology. Series A, Biological sciences and medical sciences · 2023Article
- Multidisciplinary Intensive Rehabilitation Program for People with Parkinson's Disease: Gaps between the Clinic and Real-World Mobility.International journal of environmental research and public health · 2023Article
- Association of Statins With Cerebral Atherosclerosis and Incident Parkinsonism in Older Adults.Neurology · 2022Article
- Mixed Neuropathologies, Neural Motor Resilience and Target Discovery for Therapies of Late-Life Motor Impairment.Frontiers in human neuroscience · 2022Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
objectiveWe examined the association of physical activity, postmortem brain pathologies, and parkinsonism proximate to death in older adults.
methodsWe studied the brains of 447 older decedents participating in a clinical-autopsy cohort study. We deployed a wrist worn activity monitor to record total daily physical activity during everyday living in the community-setting. Parkinsonism was assessed with 26 items of a modified motor portion of Unified Parkinson's Disease Rating Scale (UPDRS). We used linear regression models, controlling for age and sex, to examine the association of physical activity with parkinsonism with and without indices of Alzheimer's disease and related disorders (ADRD) pathologies. In separate models, we added interaction terms to examine if physical activity modified the associations of brain pathologies with parkinsonism.
resultsMean age at death was 90.9 (SD, 6.2), mean severity of parkinsonism was 14.1 (SD, 9.2, Range 0-59.4), and 350 (77%) had evidence of more than one ADRD pathologies. Higher total daily physical activity was associated with less severe parkinsonism (Estimate, -0.315, S.E., 0.052, p<0.001). The association of more physical activity with less severe parkinsonism persisted after adding terms for ten brain pathologies (Estimate, -0.283, S.E., 0.052, p<0.001). The associations of brain pathologies with more severe parkinsonism did not vary with the level of physical activity.
conclusionThe association of higher physical activity with less severe parkinsonism may be independent of the presence of ADRD brain pathologies. Further work is needed to identify mechanisms through which physical activity may maintain motor function in older adults.
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Registered trials
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