Evidence map›Paper›PMID 32347622›Full record

ArticleChembiochem : a European journal of chemical biology2020

Coumarin-Tagged Dinuclear Trithiolato-Bridged Ruthenium(II)⋅Arene Complexes: Photophysical Properties and Antiparasitic Activity.

Oksana Desiatkina, Emilia Păunescu, Martin Mösching, Nicoleta Anghel, Ghalia Boubaker, Yosra Amdouni, Andrew Hemphill, Julien Furrer

Open access · hybridAbstract read
In one paragraph

Article in Chembiochem : a European journal of chemical biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.5field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 26 citations in OpenAlex.

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  8. Building up PtChembiochem : a European journal of chemical biology · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Oksana DesiatkinaDepartment of Chemistry and Biochemistry, University of Bern, Freiestrasse 3, 3012, Bern, Switzerland.
Emilia PăunescuDepartment of Chemistry and Biochemistry, University of Bern, Freiestrasse 3, 3012, Bern, Switzerland.
Martin MöschingDepartment of Chemistry and Biochemistry, University of Bern, Freiestrasse 3, 3012, Bern, Switzerland.
Nicoleta AnghelInstitute of Parasitology Vetsuisse Faculty, University of Bern, Länggass-Strasse 122, 3012, Bern, Switzerland.
Ghalia BoubakerInstitute of Parasitology Vetsuisse Faculty, University of Bern, Länggass-Strasse 122, 3012, Bern, Switzerland.
Yosra AmdouniInstitute of Parasitology Vetsuisse Faculty, University of Bern, Länggass-Strasse 122, 3012, Bern, Switzerland.
Andrew HemphillInstitute of Parasitology Vetsuisse Faculty, University of Bern, Länggass-Strasse 122, 3012, Bern, Switzerland.ORCID 0000-0002-0622-2128
Julien FurrerDepartment of Chemistry and Biochemistry, University of Bern, Freiestrasse 3, 3012, Bern, Switzerland.ORCID 0000-0003-2096-0618
University of Bern · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The synthesis, characterization, photophysical and biological properties of 13 new conjugate coumarin-diruthenium(II)⋅arene complexes against Toxoplasma gondii are presented. For all conjugate organometallic unit/coumarins, an almost complete loss of fluorescence efficacy was observed. However, the nature of the fluorophore, the type of bonding, the presence and length of a linker between the coumarin dye and the ruthenium(II) moiety, and the number of dye units influenced their biological properties. The in vitro activity against a transgenic T. gondii strain grown in human foreskin fibroblasts (HFF) leads to IC

Indexed as

AnimalsAntiparasitic AgentsCell ProliferationCells, CulturedCoordination ComplexesCoumarinsCrystallography, X-RayFemaleHumansMiceMice, Inbred BALB CModels, MolecularMolecular StructureParasitic Sensitivity TestsPhotochemical ProcessesRutheniumAntiparasitic AgentsCoordination ComplexescoumarinCoumarinsRutheniumSulfhydryl Compoundsantiprotozoal agentscoumarincytotoxicityrutheniumsandwich complexesToxoplasma gondii

Identifiers

PMID32347622
PMCPMC7586963
OpenAlexW3020256910

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.