ArticleBrazilian journal of microbiology : [publication of the Brazilian Society for Microbiology]2020
Retrospective study of porcine circovirus 3 (PCV3) in swine tissue from Brazil (1967-2018).
Article in Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology], 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Epidemiological and genetic variation analysis of emerging porcine circovirus type 3 in Henan Province, 2023-2024.BMC veterinary research · 2026Article
- Concurrent histological lesions and molecular detection of porcine circovirus 3 in pigs with skeletal abnormalities and humpy-back posture.Veterinary pathology · 2026Article
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- Dynamics of PCV2 and PCV3 in the Serum and Oral Fluids of Pigs After PCV2 Vaccination in a Commercial Farm.Vaccines · 2024Article
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- Molecular detection of emergingHeliyon · 2024Article
- Genetic and In Vitro Characteristics of a Porcine Circovirus Type 3 Isolate from Northeast China.Veterinary sciences · 2023Article
- Detection and Complete Genomic Analysis ofPathogens (Basel, Switzerland) · 2023Article
- Molecular detection of porcine circovirus (PCV2 and PCV3), torque teno swine virus 1 and 2 (TTSuV1 and TTSuVk2), and histopathological findings in swine organs submitted to regular slaughter in Southeast, Brazil.Brazilian journal of veterinary medicine · 2023Article
- Porcine circovirus 3: a new challenge to explore.Frontiers in veterinary science · 2023Review
- Retrospective assessment of porcine circovirus 3 (PCV-3) in formalin-fixed, paraffin-embedded tissues from pigs affected by different clinical-pathological conditions.Porcine health management · 2022Article
- Phylodynamic analysis of current Porcine circovirus 4 sequences: Does the porcine circoviruses evolutionary history repeat itself?Transboundary and emerging diseases · 2022Article
- High Prevalence of Porcine Circovirus 3 in Hungarian Pig Herds: Results of a Systematic Sampling Protocol.Viruses · 2022Article
- Review
- Porcine circovirus 3 (PCV-3) as a causal agent of disease in swine and a proposal of PCV-3 associated disease case definition.Transboundary and emerging diseases · 2021Review
- Review
- Retrospective surveillance of porcine circovirus 4 in pigs in Inner Mongolia, China, from 2016 to 2018.Archives of virology · 2021Article
- Pathogenic Characterization of a Porcine Circovirus Type 3 Isolate from Heilongjiang, China.Disease markers · 2021Article
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7 authors.
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Abstract
In this study, we report the molecular diagnosis and retrospective study of porcine circovirus 3 (PCV3) in frozen and formalin-fixed paraffin-embedded swine tissues (FFPE) collected from 1967 to 2018 in southeastern Brazil (Espírito Santo and Rio de Janeiro states). Frozen tissues from 35 pigs and FFPE tissues from 143 pigs were tested by nested PCR, targeting the PCV3 partial capsid gene. Bidirectional sequencing of 16 positive samples was performed, followed by sequence analysis and haplotype networks. A total of 26/178 samples (14.6%) tested positive for PCV3: 14/35 (40%) frozen tissue and 12/143 (8.4%) FFPE tissue. PCV3 was detected in the 1960s, 1970s, 2000s, and 2010s with the characterization of types PCV3a and PCV3b. A star-like distribution was observed in the grid of haplotypes, with a low haplotype diversity and more recent dispersal of the virus. A total of 40% of asymptomatic animals considered fit for slaughter tested positive for PCV3. In conclusion, PCV3 DNA was detected over 51 years of study, prior to initial reports and, so far, the sample detected in 1967 is the oldest partial capsid sequence described. The circulation of two different genotypes was reported, suggesting more than one introduction event of this virus into Brazil. Moreover, taken together, our studies indicated an ancient origin of PCV3 and its circulation in asymptomatic animals in Brazilian herds.
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