Evidence map›Paper›PMID 32347446›Full record

ReviewCurrent HIV/AIDS reports2020

Artificial Intelligence and Machine Learning for HIV Prevention: Emerging Approaches to Ending the Epidemic.

Julia L Marcus, Whitney C Sewell, Laura B Balzer, Douglas S Krakower

Registry-linked trialOpen access · greenAbstract readReview
In one paragraph

Review in Current HIV/AIDS reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01864603 (Sustainable East Africa Research in Community Health), which is not on this map. Cited by 73 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
73citing papers in PubMed, 5 pooled it
1.5field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01864603 nacompletednot on this map

Sustainable East Africa Research in Community Health

TypeinterventionalSponsorUniversity of California, San FranciscoRan2013 to 2021Enrolled150,395ConditionsHIV, Tuberculosis, Hypertension, DiabetesArmsUniversal ART in a streamlined care model, Annual Community Health Campaigns, Targeted PrEP and Targeted testing interventions, Baseline community-based HIV and multi-disease testing
3 · Its place in the literature

Who cites it

73 citing papers in PubMed, 5 syntheses or guidelines pooled it, 132 citations in OpenAlex.

  1. Pooled it
  2. Machine learning for personalized risk assessment of HIV, syphilis, gonorrhoea and chlamydia: A systematic review and meta-analysis.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2025
    Pooled it
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  6. Article
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  12. Integrating HIV services in an era of global change.Journal of the International AIDS Society · 2026
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13 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 4 institutions in 1 country.

Julia L MarcusHarvard Medical School and Harvard Pilgrim Health Care Institute, 401 Park Dr, Ste 401, Boston, MA, 02215, USA. julia_marcus@harvardpilgrim.org.
Whitney C SewellHarvard Medical School and Harvard Pilgrim Health Care Institute, 401 Park Dr, Ste 401, Boston, MA, 02215, USA.
Laura B BalzerUniversity of Massachusetts Amherst, 715 North Pleasant St, Amherst, MA, 01003, USA.
Douglas S KrakowerBeth Israel Deaconess Medical Center, Division of Infectious Diseases, 110 Francis St., W/LMOB Suite GB, Boston, MA, 02215, USA.
Beth Israel Deaconess Medical Center · USHarvard Pilgrim Health Care · USHarvard University · USUniversity of Massachusetts Amherst · US

Funding

Leadership and Operations Center (LOC), AIDS Clinical Trials Group (ACTG); LOC 1/UM1AI068636 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Joseph J Eron, RAJESH T GANDHI · 2011 to 2026
$1073.1M
The impact of HIV viral diversity and cellular immunity on HIV pathogenesisP30AI060354 · NIAID · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI RAJESH T GANDHI · 2004 to 2026
$94.4M
Reducing Failure-to-Initiate ART: Streamlined ART Start Strategy (START)U01AI099959 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HAVLIR, DIANE V · 2012 to 2016
$39.7M
EHR-Based Prediction Models to Improve PrEP Use in Community Health CentersR34MH122291 · NIMH · HARVARD PILGRIM HEALTH CARE, INC. · PI KRAKOWER, DOUGLAS SCOTT, MARCUS, JULIA L. · 2020 to 2022
$743k
Optimizing Care for HIV/HCV-Coinfected Patients in the New HCV Treatment EraK01AI122853 · NIAID · KAISER FOUNDATION RESEARCH INSTITUTE · PI MARCUS, JULIA L. · 2016 to 2020
$655k
NIAID NIH HHS K01 AI122853NIAID NIH HHS P30 AI060354NIAID NIH HHS U01 AI099959NIAID NIH HHS UM1 AI068636NIMH NIH HHS R34 MH122291PEPFAR
6 · The paper itself

Abstract

purpose of reviewWe review applications of artificial intelligence (AI), including machine learning (ML), in the field of HIV prevention. RECENT

findingsML approaches have been used to identify potential candidates for preexposure prophylaxis (PrEP) in healthcare settings in the USA and Denmark and in a population-based research setting in Eastern Africa. Although still in the proof-of-concept stage, other applications include ML with smartphone-collected and social media data to promote real-time HIV risk reduction, virtual reality tools to facilitate HIV serodisclosure, and chatbots for HIV education. ML has also been used for causal inference in HIV prevention studies. ML has strong potential to improve delivery of PrEP, with this approach moving from development to implementation. Development and evaluation of AI and ML strategies for HIV prevention may benefit from an implementation science approach, including qualitative assessments with end users, and should be developed and evaluated with attention to equity.

Indexed as

Machine LearningAcquired Immunodeficiency SyndromeAfrica, EasternAnti-HIV AgentsEpidemicsHumansPre-Exposure ProphylaxisRisk Reduction BehaviorAnti-HIV AgentsArtificial intelligenceBig dataData scienceHuman immunodeficiency virus (HIV)Machine learningPrevention

Identifiers

PMID32347446
PMCPMC7260108
OpenAlexW3019693485

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.