ReviewJapanese journal of radiology2020
Morphometric changes and imaging findings of diffuse liver disease in relation to intrahepatic hemodynamics.
Review in Japanese journal of radiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 22 citations in OpenAlex.
- Renal elastography in kidney disease: Current evidence, limitations, and future directions.World journal of nephrology · 2026Review
- Lumped parameter modeling of changes in liver hemodynamics due to cirrhosis.Biomechanics and modeling in mechanobiology · 2026Article
- Hyperintense liver lesions on hepatobiliary phase of gadoxetic acid-enhanced magnetic resonance imaging: clinical insights and significance.Abdominal radiology (New York) · 2026Review
- Potential to Avoid Invasive Procedures for Atypical Focal Nodular Hyperplasia (FNH) and FNH-like Lesions Based on MR Findings.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2026Article
- Three-Dimensional Volumetric Iodine Mapping of the Liver Segment Derived from Contrast-Enhanced Dual-Energy CT for the Assessment of Hepatic Cirrhosis.Tomography (Ann Arbor, Mich.) · 2025Article
- Non-invasive assessment of liver function in cirrhosis using iodine density difference between the portal vein and hepatic vein on spectral CT: correlation with Child-Pugh grades.BMC medical imaging · 2025Article
- Article
- Novel microwave assisted carboxymethyl-graphene oxide and its hepatoprotective activity.BMC pharmacology & toxicology · 2024Article
- Laterality of CT-measured hepatic extracellular volume fraction in patients with chronic thromboembolic pulmonary hypertension.The international journal of cardiovascular imaging · 2024Article
- Article
- Extracellular volume fraction obtained by dual-energy CT depicting the etiological differences of liver fibrosis.Abdominal radiology (New York) · 2023Article
- Liver cirrhosis: relationship between fibrosis-associated hepatic morphological changes and portal hemodynamics using four-dimensional flow magnetic resonance imaging.Japanese journal of radiology · 2023Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Diffuse hepatic diseases have a variety of etiologies, with each showing characteristic morphometric changes. These changes are closely related to micro- and macro-level intrahepatic hemodynamics, in addition to the specific underlying pathophysiology. Short-term disorders in intrahepatic hemodynamics caused by each pathophysiological condition are compensated for by the balance of blood perfusion systems using potential trans-sinusoidal, transversal, and transplexal routes of communication (micro-hemodynamics), while long-term alterations to the intrahepatic hemodynamics result in an increase in total hepatic vascular resistance. Blood flow disorders induced by this increased vascular resistance elicit hepatic cellular necrosis and fibrosis. These changes should be uniformly widespread throughout the whole liver. However, morphometric changes do not occur uniformly, with shrinkage or enlargement not occurring homogeneously. Against this background, several macro-intrahepatic hemodynamic effects arise, such as asymmetrical and complicating morphometric structures of the liver, intricate anatomy of portal venous flow and hepatic venous drainage, and zonal differentiation between central and peripheral zones. These hemodynamic factors and pathophysiological changes are related to characteristic morphometric changes in a complicated manner, based on the combination of selective atrophy and compensatory hypertrophy (atrophy-hypertrophy complex). These changes can be clearly depicted on CT and MR imaging.
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