Evidence map›Paper›PMID 32347360›Full record

ReviewAnalytical and bioanalytical chemistry2020

Biological applications of microchip electrophoresis with amperometric detection: in vivo monitoring and cell analysis.

Kelci M Schilly, Shamal M Gunawardhana, Manjula B Wijesinghe, Susan M Lunte

Abstract readReview
In one paragraph

Review in Analytical and bioanalytical chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Kelci M SchillyDepartment of Chemistry, University of Kansas, 1567 Irving Hill Road, Lawrence, KS, 66045, USA.
Shamal M GunawardhanaDepartment of Chemistry, University of Kansas, 1567 Irving Hill Road, Lawrence, KS, 66045, USA.
Manjula B WijesingheDepartment of Chemistry, University of Kansas, 1567 Irving Hill Road, Lawrence, KS, 66045, USA.
Susan M LunteDepartment of Chemistry, University of Kansas, 1567 Irving Hill Road, Lawrence, KS, 66045, USA. slunte@ku.edu.

Funding

Understanding the mechanobiology of stem cells in a microengineered 3D cardiac tissue environment with cardiomyopathyP20GM103638 · NIGMS · UNIVERSITY OF KANSAS LAWRENCE · PI LUNTE, SUSAN M · 2012 to 2021
$22.1M
University of Kansas Alzheimer's Disease Core CentersP30AG035982 · NIA · UNIVERSITY OF KANSAS MEDICAL CENTER · PI BROOKS, WILLIAM M. · 2011 to 2020
$16.6M
TRAINING GRANT IN DYNAMIC ASPECTS OF CHEMICAL BIOLOGYT32GM008545 · NIGMS · UNIVERSITY OF KANSAS LAWRENCE · PI LAMB, AUDREY L · 1994 to 2019
$4.9M
Analytical Methods for Investigating Peptide TransportR01NS042929 · NINDS · UNIVERSITY OF KANSAS LAWRENCE · PI LUNTE, SUSAN M · 2002 to 2011
$2.3M
A self-contained wireless modular separation based sensor systemR43NS064644 · NINDS · PINNACLE TECHNOLOGY, INC · PI JOHNSON, DAVID A, LUNTE, SUSAN M · 2009 to 2010
$721k
Microanalytical methods for the detection of reactive nitrogen speciesR21NS061202 · NINDS · UNIVERSITY OF KANSAS LAWRENCE · PI LUNTE, SUSAN M · 2009 to 2010
$410k
National Science Foundation CHE -1411993NIA NIH HHS P30 AG035982NIGMS NIH HHS P20 GM103638NIGMS NIH HHS T32 GM008545NIGMS NIH HHS T32GM008545NINDS NIH HHS R01 NS042929NINDS NIH HHS R21 NS061202NINDS NIH HHS R21NS061202NINDS NIH HHS R43 NS064644
6 · The paper itself

Abstract

Microchip electrophoresis with amperometric detection (ME-EC) is a useful tool for the determination of redox active compounds in complex biological samples. In this review, a brief background on the principles of ME-EC is provided, including substrate types, electrode materials, and electrode configurations. Several different detection approaches are described, including dual-channel systems for dual-electrode detection and electrochemistry coupled with fluorescence and chemiluminescence. The application of ME-EC to the determination of catecholamines, adenosine and its metabolites, and reactive nitrogen and oxygen species in microdialysis samples and cell lysates is also detailed. Lastly, approaches for coupling of ME-EC with microdialysis sampling to create separation-based sensors that can be used for near real-time monitoring of drug metabolism and neurotransmitters in freely roaming animals are provided. Graphical abstract.

Indexed as

AnimalsElectrochemical TechniquesElectrodesElectrophoresis, MicrochipEquipment DesignMiceMicrodialysisSheepElectrochemical detectionElectrophoresisMicrodialysisNeurotransmittersNitric oxide

Identifiers

PMID32347360
PMCPMC8130646

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.