Evidence map›Paper›PMID 32347323›Full record

ArticleIntensive care medicine2020

Facing COVID-19 in the ICU: vascular dysfunction, thrombosis, and dysregulated inflammation.

Daniel E Leisman, Clifford S Deutschman, Matthieu Legrand

Registry-linked trialOpen access · bronzeAbstract readComment
In one paragraph

Article in Intensive care medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04408235 (Randomised Controlled Trial Comparing High Versus Low LMWH Dosages in Hospitalized Patients With Severe COVID-19 Pneumonia and Coagulopathy Not Requiring Invasive Mechanical Ventilation), which is not on this map. Cited by 191 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
191citing papers in PubMed, 4 pooled it
8.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04408235 phase3unknown statusnot on this map

Randomised Controlled Trial Comparing High Versus Low LMWH Dosages in Hospitalized Patients With Severe COVID-19 Pneumonia and Coagulopathy Not Requiring Invasive Mechanical Ventilation

TypeinterventionalSponsorAzienda Ospedaliero-Universitaria di ModenaRan2020 to 2021Enrolled300ConditionsCOVID, Pneumonia, Viral, Coagulation DisorderArmsEnoxaparin
3 · Its place in the literature

Who cites it

191 citing papers in PubMed, 4 syntheses or guidelines pooled it, 345 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
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  4. Meta-analysis of coagulation parameters associated with disease severity and poor prognosis of COVID-19.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2020
    Pooled it
  5. Article
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  7. Observational
  8. Metabolic signature of COVID-19 progression: potential prognostic markers for severity and outcome.Metabolomics : Official journal of the Metabolomic Society · 2025
    Article
  9. Review
  10. Article
  11. Review
  12. Article
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  16. Review
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  18. Observational
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131 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

Daniel E LeismanIcahn School of Medicine at Mount Sinai, New York, NY, USA.
Clifford S DeutschmanDepartments of Pediatrics, Molecular Medicine and Surgery, Cohen Children's Medical Center, Feinstein Institute for Medical Research, Northwell Health, Manhasset, NY, USA.
Matthieu LegrandDepartment of Anesthesia and Perioperative Care, University of California, San Francisco, CA, USA. matthieu.legrand@ucsf.edu.
Cohen Children's Medical Center · USIcahn School of Medicine at Mount Sinai · USUniversity of California, San Francisco · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Respiratory Distress SyndromeThrombosisBetacoronavirusCoronavirus InfectionsCOVID-19HumansInflammationIntensive Care UnitsPandemicsPneumonia, ViralSARS-CoV-2

Identifiers

PMID32347323
PMCPMC7186535
OpenAlexW3018529391

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.