Evidence map›Paper›PMID 32347296›Full record

ArticleBioscience reports2020

Identification of co-expressed genes associated with MLL rearrangement in pediatric acute lymphoblastic leukemia.

Hao Zhang, Bei Liu, Juan Cheng, Haizhen Ma, Zijian Li, Yaming Xi

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PubMed Full text at PMC Publisher
In one paragraph

Article in Bioscience reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Hao ZhangDepartment of Hematology, The First Hospital of Lanzhou University, Lanzhou, Gansu Province, China.
Bei LiuDepartment of Hematology, The First Hospital of Lanzhou University, Lanzhou, Gansu Province, China.
Juan ChengDepartment of Hematology, The First Hospital of Lanzhou University, Lanzhou, Gansu Province, China.
Haizhen MaDepartment of Hematology, The First Hospital of Lanzhou University, Lanzhou, Gansu Province, China.
Zijian LiDepartment of Hematology, The First Hospital of Lanzhou University, Lanzhou, Gansu Province, China.
Yaming XiDepartment of Hematology, The First Hospital of Lanzhou University, Lanzhou, Gansu Province, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Rearrangements involving the mixed lineage leukemia (MLL) gene are common adverse prognostic factors of pediatric acute lymphoblastic leukemia (ALL). Even allogeneic hematopoietic stem cell transplantation does not improve the outcome of ALL cases with some types of MLL rearrangements. The aim of the present study was to identify the co-expressed genes that related to MLL rearrangement (MLL-r) and elucidate the potential mechanisms of how MLL-r and their partner genes lead to leukemogenesis. Gene co-expression networks were constructed using the gene expression data and sample traits of 204 pretreated pediatric ALL patients, and co-expression modules significantly related to the MLL-r were screened out. Gene ontology annotation and Kyoto Encyclopedia of Genes and Genomes pathway analysis of the module genes were performed. Hub genes were identified and their expression levels were analyzed in samples with or without MLL-r and the results were validated by an independent investigation. Furthermore, the relationships between the hub genes and sample traits were analyzed. In total, 21 co-expression modules were identified. The green module was positively correlated with MLL-r. PROM1, LGALS1, CD44, FUT4 and HOXA10 were identified as hub genes, which were involved in focal adhesion, calcium-dependent phospholipid binding, connective tissue development and transcriptional misregulation in cancer. The expression levels of the five hub genes were significantly increased in MLL-r samples, and the results were further validated. PROM1, LGALS1, CD44 and HOXA10 were positively related to the leukocyte count. These findings might provide novel insight regarding the mechanisms and potential therapeutic targets for pediatric ALL with MLL-r.

Indexed as

Gene Expression Regulation, LeukemicGene RearrangementAC133 AntigenAdolescentAge FactorsBiomarkers, TumorChildChild, PreschoolDatabases, GeneticFemaleGalectin 1Gene FusionGene Regulatory NetworksGenetic Predisposition to DiseaseHistone-Lysine N-MethyltransferaseHomeobox A10 ProteinsAC133 AntigenBiomarkers, TumorCD44 protein, humanGalectin 1Histone-Lysine N-MethyltransferaseHomeobox A10 ProteinsHOXA10 protein, humanHyaluronan ReceptorsKMT2A protein, humanLGALS1 protein, humanMyeloid-Lymphoid Leukemia ProteinPROM1 protein, humanacute lymphoblastic leukemiaMLL rearrangementpediatricWGCNA

Identifiers

PMID32347296
PMCPMC7953500

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