ArticleCirculation research2020
ZO-1 Regulates Intercalated Disc Composition and Atrioventricular Node Conduction.
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Article in Circulation research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20 citing papers in PubMed, 25 citations in OpenAlex.
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- Genetic loci responsible for atrioventricular block in children.Frontiers in cell and developmental biology · 2026Review
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- Translationally controlled tumor protein interacts with connexin 43 and facilitates intercellular coupling between cardiomyocytes.Frontiers in cell and developmental biology · 2025Article
- The intercalated disc: a unique organelle for electromechanical synchrony in cardiomyocytes.Physiological reviews · 2023Review
- Embryonic Hyperglycemia Disrupts Myocardial Growth, Morphological Development, and Cellular Organization: An In Vivo Experimental Study.Life (Basel, Switzerland) · 2023Article
- Zonula Occludens Proteins Signaling in Inflammation and Tumorigenesis.International journal of biological sciences · 2023Review
- Hippo-Yap Signaling Maintains Sinoatrial Node Homeostasis.Circulation · 2022Article
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- Understanding the molecular basis of cardiomyopathy.American journal of physiology. Heart and circulatory physiology · 2022Review
- Supplementation with paraformic acid in the diet improved intestinal development through modulating intestinal inflammation and microbiota in broiler chickens.Frontiers in microbiology · 2022Article
- Extracellular matrix remodeling is associated with the survival of cardiomyocytes in the subendocardial region of the ischemic myocardium.Experimental biology and medicine (Maywood, N.J.) · 2021Article
- Zippering Up a Role for ZO-1 in Atrioventricular Node Conduction and Disease.Circulation research · 2020Article
- Mechanism of Left Ventricular Dysfunction due to Permanent Pacemaker: An Analysis of miR-155, sTNFR-2, MMP-9, N-Cad, and ZO-1.Journal of cardiovascular echographyArticle
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Authors and funding
22 authors at 4 institutions in 1 country.
Wenli DaiFrom the Departments of Pathology (W.D., H.L.S., Y.L., L.S., C.R.W.), The University of Chicago, IL.
Rangarajan D NadadurPediatrics, Pathology, and Human Genetics (R.D.N., K.M.S., M.G., I.P.M.), The University of Chicago, IL.
Jaclyn A BrennanDepartment of Biomedical Engineering, The George Washington University, Washington, DC (J.A.B., I.R.E.).
Heather L SmithFrom the Departments of Pathology (W.D., H.L.S., Y.L., L.S., C.R.W.), The University of Chicago, IL.
Kaitlyn M ShenPediatrics, Pathology, and Human Genetics (R.D.N., K.M.S., M.G., I.P.M.), The University of Chicago, IL.
Margaret GadekPediatrics, Pathology, and Human Genetics (R.D.N., K.M.S., M.G., I.P.M.), The University of Chicago, IL.
Brigitte LaforestMedicine, Section of Cardiology (B.L., M.T.B.), The University of Chicago, IL.
Mingyi WangLaboratory of Cardiovascular Science, National Institution on Aging-NIH, Baltimore, MD (M.W., J.Z., B.D.Z., E.G.L.).
Joanna GemelPediatrics (J.G., E.C.B.), The University of Chicago, IL.
Ye LiFrom the Departments of Pathology (W.D., H.L.S., Y.L., L.S., C.R.W.), The University of Chicago, IL.
Jing ZhangLaboratory of Cardiovascular Science, National Institution on Aging-NIH, Baltimore, MD (M.W., J.Z., B.D.Z., E.G.L.).
Bruce D ZimanLaboratory of Cardiovascular Science, National Institution on Aging-NIH, Baltimore, MD (M.W., J.Z., B.D.Z., E.G.L.).
Jiajie YanPhysiology and Biophysics, Rush University, Chicago, IL (J.Y., X.A.).
Xun AiPhysiology and Biophysics, Rush University, Chicago, IL (J.Y., X.A.).
Eric C BeyerPediatrics (J.G., E.C.B.), The University of Chicago, IL.
Edward G LakataLaboratory of Cardiovascular Science, National Institution on Aging-NIH, Baltimore, MD (M.W., J.Z., B.D.Z., E.G.L.).
Narayanan KasthuriNeurobiology (N.K.), The University of Chicago, IL.
Igor R EfimovDepartment of Biomedical Engineering, The George Washington University, Washington, DC (J.A.B., I.R.E.).
Michael T BromanMedicine, Section of Cardiology (B.L., M.T.B.), The University of Chicago, IL.
Ivan P MoskowitzPediatrics, Pathology, and Human Genetics (R.D.N., K.M.S., M.G., I.P.M.), The University of Chicago, IL.
Le Shen *From the Departments of Pathology (W.D., H.L.S., Y.L., L.S., C.R.W.), The University of Chicago, IL.
Christopher R Weber *From the Departments of Pathology (W.D., H.L.S., Y.L., L.S., C.R.W.), The University of Chicago, IL.
University of Chicago · USNational Institute on Aging · USGeorge Washington University · USRush University · US
Funding
MEDICAL SCIENTIST TRAININGT32GM007281 · NIGMS · UNIVERSITY OF CHICAGO · PI CLARK, MARCUS RAMSAY · 1985 to 2022
$32.1MZO-1-MEDIATED PROTEIN INTERACTIONS: REGULATORS AND INTEGRATORS OF DIVERSE EPITHELIAL FUNCTIONS IN HEALTH AND DISEASER01DK061931 · NIDDK · UNIVERSITY OF CHICAGO · PI JERROLD R. TURNER · 2001 to 2026
$15.0MMULTIDISCIPLINARY CARDIAC SCIENCEST32HL007381 · NHLBI · UNIVERSITY OF CHICAGO · PI JEANNE M DECARA, Yoav Gilad · 1985 to 2026
$12.5MTherapeutic targeting of protein interactions to reverse MLCK1-mediated intestinal barrier loss and ameliorate disease.R01DK068271 · NIDDK · UNIVERSITY OF CHICAGO · PI JERROLD R. TURNER · 2005 to 2026
$11.3MThe Stress Response Kinase JNK and Alcohol Evoked Atrial FibrillationR01AA024769 · NIAAA · OHIO STATE UNIVERSITY · PI AI, XUN, CHEN, SUI RONG WAYNE · 2017 to 2021
$3.3MHeart-platelet crosstalk: JNK, AF, and thrombogenesisR01HL146744 · NHLBI · RUSH UNIVERSITY MEDICAL CENTER · PI Xun Ai, Yuchi Han · 2019 to 2026
$3.2MAtrial and blood JNK in Postoperative AFR01HL168728 · NHLBI · OHIO STATE UNIVERSITY · PI Xun Ai · 2023 to 2026
$2.7MTranscriptional Control of Cardiac Conduction System Function by T-box GenesR01HL114010 · NHLBI · UNIVERSITY OF CHICAGO · PI MOSKOWITZ, IVAN PAUL, NOBREGA, MARCELO A. · 2012 to 2016
$2.6MGene Regulatory Networks for Cardiac MorphogenesisR01HL126509 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI CONLON, FRANK LEO, CRISTEA, ILEANA M. · 2017 to 2020
$2.5MGene Regulatory Non-Coding RNAs in the Human HeartR01HL148719 · NHLBI · UNIVERSITY OF CHICAGO · PI MOSKOWITZ, IVAN PAUL, RUTHENBURG, ALEXANDER JACKSON · 2019 to 2022
$2.3MFunctional Assays to Screen Genomic HitsR33HL123857 · NHLBI · UNIVERSITY OF CHICAGO · PI MOSKOWITZ, IVAN PAUL, NOBREGA, MARCELO A. · 2016 to 2018
$1.5MNHLBI NIH HHS R01 HL114010NHLBI NIH HHS R01 HL126509NHLBI NIH HHS R01 HL146744NHLBI NIH HHS R01 HL148719NHLBI NIH HHS R01 HL168728NHLBI NIH HHS R33 HL123857NHLBI NIH HHS T32 HL007381NIAAA NIH HHS R01 AA024769NIDDK NIH HHS R01 DK061931NIDDK NIH HHS R01 DK068271NIGMS NIH HHS T32 GM007281
Abstract
rationaleZO-1 (Zona occludens 1), encoded by the tight junction protein 1 (
objectiveWe aim to determine the role of ZO-1 in cardiac function. METHODS AND
resultsInducible cardiomyocyte-specific
conclusionsZO-1 is a key protein responsible for maintaining appropriate AV node conduction through maintaining gap junction protein localization.
Indexed as
Heart RateAnimalsAtrioventricular NodeConnexin 43ConnexinsGap Junction alpha-5 ProteinHumansMaleMiceMice, Inbred C57BLMyocytes, CardiacMyosin Heavy ChainsPotassium Channels, Voltage-GatedZonula Occludens-1 ProteinConnexin 43ConnexinsGap Junction alpha-5 ProteinKcne1 protein, mouseMyh6 protein, mouseMyosin Heavy ChainsPotassium Channels, Voltage-GatedTjp1 protein, mouseZonula Occludens-1 Proteinatrioventricular blockconnexinscytoskeletonintercellular junctionstight junctions
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.