Evidence map›Paper›PMID 32346955›Full record

ArticleChembiochem : a European journal of chemical biology2020

Tuning the Innate Immune Response to Cyclic Dinucleotides by Using Atomic Mutagenesis.

Yao Li, Andrea Fin, Alexander R Rovira, Yichi Su, Andrew B Dippel, Jonathan Andrés Valderrama, Angelica M Riestra, Victor Nizet, Ming C Hammond, Yitzhak Tor

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chembiochem : a European journal of chemical biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Isomorphic Fluorescent Nucleosides.Accounts of chemical research · 2024
    Article
  3. Article
  4. Chemical Synthesis of the Fluorescent, Cyclic Dinucleotides cChembiochem : a European journal of chemical biology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Yao LiDepartment of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093-0358, USA.
Andrea FinDepartment of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093-0358, USA.
Alexander R RoviraDepartment of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093-0358, USA.
Yichi SuDepartment of Chemistry and Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA.
Andrew B DippelDepartment of Chemistry and Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA.
Jonathan Andrés ValderramaCollaborative to Halt Antibiotic-Resistant Microbes, Department of Pediatrics, University of California, San Diego, La Jolla, CA 92093-0760, USA.
Angelica M RiestraCollaborative to Halt Antibiotic-Resistant Microbes, Department of Pediatrics, University of California, San Diego, La Jolla, CA 92093-0760, USA.
Victor NizetCollaborative to Halt Antibiotic-Resistant Microbes, Department of Pediatrics, University of California, San Diego, La Jolla, CA 92093-0760, USA.
Ming C HammondDepartment of Chemistry and Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA.
Yitzhak TorDepartment of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093-0358, USA.ORCID 0000-0003-3726-7799
University of California San Diego · USUniversity of California, Berkeley · USUniversity of Utah · US

Funding

Fluorescent Nucleosides and OligonucleotidesR01GM069773 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI TOR, YITZHAK · 2004 to 2020
$5.0M
Enabling High-Throughput Analysis and Single-Cell Imaging of Bacterial SignalsR01GM124589 · NIGMS · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI HAMMOND, MING CHEN · 2017 to 2025
$2.8M
NIGMS NIH HHS R01 GM069773NIGMS NIH HHS R01 GM124589
6 · The paper itself

Abstract

Cyclic dinucleotides (CDNs) trigger the innate immune response in eukaryotic cells through the stimulator of interferon genes (STING) signaling pathway. To decipher this complex cellular process, a better correlation between structure and downstream function is required. Herein, we report the design and immunostimulatory effect of a novel group of c-di-GMP analogues. By employing an "atomic mutagenesis" strategy, changing one atom at a time, a class of gradually modified CDNs was prepared. These c-di-GMP analogues induce type-I interferon (IFN) production, with some being more potent than c-di-GMP, their native archetype. This study demonstrates that CDN analogues bearing modified nucleobases are able to tune the innate immune response in eukaryotic cells.

Indexed as

Cyclic GMPImmunity, InnateInterferonsNucleotides, CyclicSignal TransductionCyclic GMPInterferonsNucleotides, Cycliccyclic dinucleotidesinnate immune responsemodified nucleosidesSTING agonists

Identifiers

PMID32346955
PMCPMC7494572
OpenAlexW3017488788

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.