Evidence map›Paper›PMID 32346539›Full record

ArticleBurns & trauma2020

Adipose-derived stem cells improve grafted burn wound healing by promoting wound bed blood flow.

Osamu Fujiwara, Anesh Prasai, Dannelys Perez-Bello, Amina El Ayadi, Irene Y Petrov, Rinat O Esenaliev, Yuriy Petrov, David N Herndon, Celeste C Finnerty, Donald S Prough and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Burns & trauma, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
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  11. Article
  12. Mesenchymal Stem Cells in Burn Wound Management.International journal of molecular sciences · 2022
    Review
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  15. Stem cell-based therapy for human diseases.Signal transduction and targeted therapy · 2022
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Osamu FujiwaraDepartment of Anesthesiology, University of Texas Medical Branch, Galveston, TX, USA.
Anesh PrasaiDepartment of Surgery, University of Texas Medical Branch, Galveston, 301 University BLVD TX 77555, USA.
Dannelys Perez-BelloDepartment of Anesthesiology, University of Texas Medical Branch, Galveston, TX, USA.
Amina El AyadiDepartment of Surgery, University of Texas Medical Branch, Galveston, 301 University BLVD TX 77555, USA.
Irene Y PetrovCenter for Biomedical Engineering, University of Texas Medical Branch, 601 Harbor Side Dr. Galveston, TX 77555, USA.
Rinat O EsenalievDepartment of Anesthesiology, University of Texas Medical Branch, Galveston, TX, USA.
Yuriy PetrovCenter for Biomedical Engineering, University of Texas Medical Branch, 601 Harbor Side Dr. Galveston, TX 77555, USA.
David N HerndonDepartment of Surgery, University of Texas Medical Branch, Galveston, 301 University BLVD TX 77555, USA.
Celeste C FinnertyDepartment of Surgery, University of Texas Medical Branch, Galveston, 301 University BLVD TX 77555, USA.
Donald S ProughDepartment of Anesthesiology, University of Texas Medical Branch, Galveston, TX, USA.
Perenlei EnkhbaatarDepartment of Anesthesiology, University of Texas Medical Branch, Galveston, TX, USA.

Funding

UTMB Clinical and Translational Science AwardUL1TR000071 · NCATS · UNIVERSITY OF TEXAS MED BR GALVESTON · PI BRASIER, ALLAN R. · 2012 to 2014
$14.4M
Effects of Chronic Catecholamine Exposure on Post-burn ScarringR01GM112936 · NIGMS · UNIVERSITY OF TEXAS MED BR GALVESTON · PI FINNERTY, CELESTE CAMPBELL · 2015 to 2019
$1.8M
NCATS NIH HHS UL1 TR000071NIGMS NIH HHS R01 GM112936
6 · The paper itself

Abstract

backgroundResearchers have explored the use of adipose-derived stem cells (ASCs) as a cell-based therapy to cover wounds in burn patients; however, underlying mechanistic aspects are not completely understood. We hypothesized that ASCs would improve post-burn wound healing after eschar excision and grafting by increasing wound blood flow via induction of angiogenesis-related pathways.

methodsTo test the hypothesis, we used an ovine burn model. A 5 cm

resultsTreatment with ASCs accelerated the patch graft growth compared to the control (

conclusionsASCs accelerated grafted skin growth possibly by increasing the blood flow via angiogenesis induced by a VEGF-dependent pathway.

Indexed as

Adipose-derived stem cellsAngiogenesisblood flowBurnVascular endothelial growth factorVEGFWound healing

Identifiers

PMID32346539
PMCPMC7175768

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.