Evidence map›Paper›PMID 32346404›Full record

ArticleLung cancer management2020

Identification of nine key genes by bioinformatics analysis for predicting poor prognosis in smoking-induced lung adenocarcinoma.

Chuanli Ren, Weixiu Sun, Xu Lian, Chongxu Han

Abstract read
In one paragraph

Article in Lung cancer management, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Identification ofFrontiers in oncology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Chuanli RenDepartment of Laboratory Medicine, Clinical Medical College, Yangzhou University, Yangzhou, PR China.ORCID https://orcid.org/0000-0002-8386-3586
Weixiu SunClinical Laboratory Diagnostics, Clinical Medical College, Dalian Medical University, Dalian, PR China.
Xu LianClinical Laboratory Diagnostics, Clinical Medical College, Dalian Medical University, Dalian, PR China.
Chongxu HanDepartment of Laboratory Medicine, Clinical Medical College, Yangzhou University, Yangzhou, PR China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo screen and identify key genes related to the development of smoking-induced lung adenocarcinoma (LUAD). MATERIALS &

methodsWe obtained data from the GEO chip dataset GSE31210. The differentially expressed genes were screened by GEO2R. The protein interaction network of differentially expressed genes was constructed by STRING and Cytoscape. Finally, core genes were screened. The overall survival time of patients with the core genes was analyzed by Kaplan-Meier method. Gene ontology and Kyoto encyclopedia of genes and genomes bioaccumulation was calculated by DAVID.

resultsFunctional enrichment analysis indicated that nine key genes were actively involved in the biological process of smoking-related LUAD.

conclusion23 core genes and nine key genes among them were correlated with adverse prognosis of LUAD induced by smoking.

Indexed as

bioinformatics analysiscore genesGSE31210lung adenocarcinomasmoking

Identifiers

PMID32346404
PMCPMC7186853

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.