ArticleJournal of aerosol science2020
Transport and deposition of hygroscopic particles in asthmatic subjects with and without airway narrowing.
Article in Journal of aerosol science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 41 citations in OpenAlex.
- Subject-Specific Whole-Lung CFPD Coupled with PBPK/PD to Predict Inhaled Bronchodilator Response in Asthmatic and Healthy Subjects.Journal of aerosol science · 2026Article
- CFD Modeling of Airflow and Aerosol Transport in the Human Respiratory System: A Comprehensive Review.Pharmaceutical research · 2026Review
- Multiscale simulation of respiratory airflow using physiologically consistent geometry and boundary conditions in OpenFOAM.Computers in biology and medicine · 2025Article
- Assessment of ventilation heterogeneity and particle deposition in asthmatics using combined SPECT/CT imaging and computational modeling approaches.European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences · 2025Article
- Transport and deposition of beclomethasone dipropionate drug aerosols with varying ethanol concentration in severe asthmatic subjects.International journal of pharmaceutics · 2023Article
- A novel approach to pulmonary bronchial tree model construction and performance index study.Frontiers in pharmacology · 2023Article
- A computed tomography imaging-based subject-specific whole-lung deposition model.European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences · 2022Article
- Modeling of the transport, hygroscopic growth, and deposition of multi-component droplets in a simplified airway with realistic thermal boundary conditions.Journal of aerosol science · 2021Article
- The effect of airway motion and breathing phase during imaging on CFD simulations of respiratory airflow.Computers in biology and medicine · 2020Article
- Longitudinal Imaging-Based Clusters in Former Smokers of the COPD Cohort Associate with Clinical Characteristics: The SubPopulations and Intermediate Outcome Measures in COPD Study (SPIROMICS).International journal of chronic obstructive pulmonary diseaseArticle
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
Abstract
This study numerically investigates the effect of hygroscopicity on transport and deposition of particles in severe asthmatic lungs with distinct airway structures. The study human subjects were selected from two imaging-based severe asthmatic clusters with one characterized by non-constricted airways and the other by constricted airways in the lower left lobe (LLL). We compared the deposition fractions of sodium chloride (NaCl) particles with a range of aerodynamic diameters (1-8 μm) in cluster archetypes under conditions with and without hygroscopic growth. The temperature and water vapor distributions in the airways were simulated with an airway wall boundary condition that accounts for variable temperature and water vapor evaporation at the interface between the lumen and the airway surface liquid layer. On average, the deposition fraction increased by about 6% due to hygroscopic particle growth in the cluster subjects with constricted airways, while it increased by only about 0.5% in those with non-constricted airways. The effect of particle growth was most significant for particles with an initial diameter of
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.