Observational studyEye (London, England)2021
Evaluation of the retinal layers and microvasculature in patients with acromegaly: a case-control OCT angiography study.
Observational study in Eye (London, England), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 16 citations in OpenAlex.
- Evaluation of static and dynamic pupil responses in patients with acromegaly with automatic pupillometer.BMC ophthalmology · 2026Article
- Impact of GH and IGF-I excess on nervous and vascular retinal structure in newly diagnosed acromegaly patients.Pituitary · 2025Article
- Intraocular Pressure (IOP) in Patients with Acromegaly versus Healthy Controls: A Systematic Review and Meta-Analysis.Vision (Basel, Switzerland) · 2024Review
- Comparison of the retinal microvasculature between compressive and glaucomatous optic neuropathy.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2023Article
- Corneal Tonometric and Morphological Changes in Patients with Acromegaly.Journal of clinical medicine · 2022Article
- Elevated IGF-1 and GH Levels Are Correlated With a Thicker Iris and Wider Anterior Chamber Angle in Treatment-Naïve Acromegaly Patients.Investigative ophthalmology & visual science · 2022Article
- Association between ocular axial length and anthropometrics of Asian adults.BMC research notes · 2021Article
- Evaluation of Peripapillary Microcirculation in Patients with Acromegaly.Beyoglu eye journal · 2021Article
- Normative Data of Superficial Retinal Vascular Plexus and the Relationship to Retinal Layers.Beyoglu eye journal · 2021Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe aim of study was to evaluate the retinal layers and macular capillary network with OCTA in acromegaly patients, to compare with healthy population.
methodsIn this prospective, observational, and comparative study, 40 acromegaly patients and 40 healthy control participants were included. Serum IGF-1 levels and disease duration of all patients were noted. Macular layers and angiography scanning was performed with a Zeiss Cirrus 5000 OCTA system. Macular thickness, RNFL, and GC-IPL values were obtained. For central vessel and perfusion density, central 6 mm was obtained and was evaluated by dividing into three groups (inner, outer, full). FAZ parameters were evaluated dividing into three groups (area, perimeter, circularity index). Analysis of the data was performed with the SPSS for Windows.
resultsThere was no significant difference between the patient group and the control group in terms of age, gender, best corrected visual acuity (BCVA), spherical equivalent (SE), intraocular pressure (IOP), and axial length (AL). The mean follow-up period after diagnosis was 11.0 ± 5.5 years. Central and mean macular thicknesses were also significantly higher in the acromegaly group (p < 0.05). Superior, inferior, and average RNFL thicknesses were also significantly thinner in the acromegaly group (p < 0.05). When OCTA parameters were compared between groups, there was a significant decrease in central vessel density (CVD) and central perfusion density (CPD) values in all regions in acromegaly group compared with controls (p < 0.05).
conclusionOur findings with OCTA show that acromegaly causes a significant capillary network decrease according to the healthy subjects.
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