ArticleNature communications2020
Prefrontal reinstatement of contextual task demand is predicted by separable hippocampal patterns.
Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Hippocampal mechanisms underlying the resolution of competition in memory and perception.Nature communications · 2026Article
- Adaptive behavior is guided by integrated representations of controlled and non-controlled information.eLife · 2026Article
- Hippocampal patterns and associative memory: Distinct intracranial EEG temporal encoding patterns support memory.bioRxiv : the preprint server for biology · 2026Article
- Reward masks the learning of cognitive control demand.Cognitive neurodynamics · 2025Article
- Adaptive behavior is guided by integrated representations of controlled and non-controlled information.bioRxiv : the preprint server for biology · 2025Article
- Schemas, reinforcement learning and the medial prefrontal cortex.Nature reviews. Neuroscience · 2025Review
- Cost-benefit tradeoff mediates the transition from rule-based to memory-based processing during practice.PLoS biology · 2025Article
- Semantic Anchors Facilitate Task Encoding in Continual Learning.Open mind : discoveries in cognitive science · 2025Article
- Cost-benefit Tradeoff Mediates the Rule- to Memory-based Processing Transition during Practice.bioRxiv : the preprint server for biology · 2024Article
- Article
- Reconstructing Spatiotemporal Trajectories of Visual Object Memories in the Human Brain.eNeuro · 2024Article
- Differentiation and Integration of Competing Memories: A Neural Network Model.bioRxiv : the preprint server for biology · 2024Article
- Dorsolateral prefrontal activity supports a cognitive space organization of cognitive control.eLife · 2024Article
- Memory for abstract control states does not decay with increasing retrieval delays.Psychological research · 2024Article
- Article
- Neural distinctiveness and reinstatement of hippocampal representations support unitization for associations.Brain research · 2023Article
- Encoding contexts are incidentally reinstated during competitive retrieval and track the temporal dynamics of memory interference.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Readiness to remember: predicting variability in episodic memory.Trends in cognitive sciences · 2022Review
- Abstract task representations for inference and control.Trends in cognitive sciences · 2022Review
- Episodic future thinking predicts differences in delay discounting: The mediating role of hippocampal structure.Frontiers in psychology · 2022Article
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Authors and funding
5 authors.
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Abstract
Goal-directed behavior requires the representation of a task-set that defines the task-relevance of stimuli and guides stimulus-action mappings. Past experience provides one source of knowledge about likely task demands in the present, with learning enabling future predictions about anticipated demands. We examine whether spatial contexts serve to cue retrieval of associated task demands (e.g., context A and B probabilistically cue retrieval of task demands X and Y, respectively), and the role of the hippocampus and dorsolateral prefrontal cortex (dlPFC) in mediating such retrieval. Using 3D virtual environments, we induce context-task demand probabilistic associations and find that learned associations affect goal-directed behavior. Concurrent fMRI data reveal that, upon entering a context, differences between hippocampal representations of contexts (i.e., neural pattern separability) predict proactive retrieval of the probabilistically dominant associated task demand, which is reinstated in dlPFC. These findings reveal how hippocampal-prefrontal interactions support memory-guided cognitive control and adaptive behavior.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.