Evidence map›Paper›PMID 32345974›Full record

ArticleScientific data2020

Simultaneous human intracerebral stimulation and HD-EEG, ground-truth for source localization methods.

Ezequiel Mikulan, Simone Russo, Sara Parmigiani, Simone Sarasso, Flavia Maria Zauli, Annalisa Rubino, Pietro Avanzini, Anna Cattani, Alberto Sorrentino, Steve Gibbs and 5 more

Abstract readDataset
In one paragraph

Article in Scientific data, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed.

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  7. Scalp EEG predicts intracranial brain activity in humans.bioRxiv : the preprint server for biology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Ezequiel MikulanDepartment of Biomedical and Clinical Sciences "L. Sacco", Università degli Studi di Milano, Milan, Italy.
Simone RussoDepartment of Biomedical and Clinical Sciences "L. Sacco", Università degli Studi di Milano, Milan, Italy.ORCID http://orcid.org/0000-0001-9984-4710
Sara ParmigianiDepartment of Biomedical and Clinical Sciences "L. Sacco", Università degli Studi di Milano, Milan, Italy.
Simone SarassoDepartment of Biomedical and Clinical Sciences "L. Sacco", Università degli Studi di Milano, Milan, Italy.
Flavia Maria ZauliDepartment of Biomedical and Clinical Sciences "L. Sacco", Università degli Studi di Milano, Milan, Italy.
Annalisa RubinoCentre of Epilepsy Surgery "C. Munari", Department of Neuroscience, Niguarda Hospital, Milan, Italy.
Pietro AvanziniInstitute of Neuroscience, National Research Council of Italy, Parma, Italy.
Anna CattaniDepartment of Biomedical and Clinical Sciences "L. Sacco", Università degli Studi di Milano, Milan, Italy.
Alberto SorrentinoDepartment of Mathematics, University of Genoa, Genoa, Italy.ORCID http://orcid.org/0000-0003-3457-6780
Steve GibbsCentre of Epilepsy Surgery "C. Munari", Department of Neuroscience, Niguarda Hospital, Milan, Italy.
Francesco CardinaleCentre of Epilepsy Surgery "C. Munari", Department of Neuroscience, Niguarda Hospital, Milan, Italy.
Ivana SartoriCentre of Epilepsy Surgery "C. Munari", Department of Neuroscience, Niguarda Hospital, Milan, Italy.ORCID http://orcid.org/0000-0001-5659-0730
Lino NobiliChild Neuropsychiatry Unit, IRCCS 'G. Gaslini' Institute, Genoa, Italy.
Marcello MassiminiDepartment of Biomedical and Clinical Sciences "L. Sacco", Università degli Studi di Milano, Milan, Italy.
Andrea PigoriniDepartment of Biomedical and Clinical Sciences "L. Sacco", Università degli Studi di Milano, Milan, Italy. andrea.pigorini@unimi.it.ORCID http://orcid.org/0000-0002-1856-3413

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Precisely localizing the sources of brain activity as recorded by EEG is a fundamental procedure and a major challenge for both research and clinical practice. Even though many methods and algorithms have been proposed, their relative advantages and limitations are still not well established. Moreover, these methods involve tuning multiple parameters, for which no principled way of selection exists yet. These uncertainties are emphasized due to the lack of ground-truth for their validation and testing. Here we present the Localize-MI dataset, which constitutes the first open dataset that comprises EEG recorded electrical activity originating from precisely known locations inside the brain of living humans. High-density EEG was recorded as single-pulse biphasic currents were delivered at intensities ranging from 0.1 to 5 mA through stereotactically implanted electrodes in diverse brain regions during pre-surgical evaluation of patients with drug-resistant epilepsy. The uses of this dataset range from the estimation of in vivo tissue conductivity to the development, validation and testing of forward and inverse solution methods.

Indexed as

Deep Brain StimulationElectroencephalographyAlgorithmsBrainBrain MappingDrug Resistant EpilepsyElectrodes, ImplantedHumans

Identifiers

PMID32345974
PMCPMC7189230

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.