Evidence map›Paper›PMID 32345971›Full record

ArticleNature communications2020

Artifact-free and high-temporal-resolution in vivo opto-electrophysiology with microLED optoelectrodes.

Kanghwan Kim, Mihály Vöröslakos, John P Seymour, Kensall D Wise, György Buzsáki, Euisik Yoon

Abstract read
In one paragraph

Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.

0numbers the graph read from it
0cells of the map it votes in
60citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

60 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. NeuroFlare: An mmIEEE journal of solid-state circuits · 2025
    Article
  5. Article
  6. Article
  7. Multifunctional bioelectronics for brain-body circuits.Nature reviews bioengineering · 2025
    Article
  8. Article
  9. In vivo microelectrode arrays for neuroscience.Nature reviews. Methods primers · 2025
    Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Review
  15. Journal of neural engineering · 2024
    Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Kanghwan KimDepartment of Electrical Engineering and Computer Science, University of Michigan, Ann Arbor, MI, 48109, USA.ORCID http://orcid.org/0000-0003-1144-956X
Mihály VöröslakosDepartment of Electrical Engineering and Computer Science, University of Michigan, Ann Arbor, MI, 48109, USA.
John P SeymourDepartment of Electrical Engineering and Computer Science, University of Michigan, Ann Arbor, MI, 48109, USA.ORCID http://orcid.org/0000-0002-3783-7838
Kensall D WiseDepartment of Electrical Engineering and Computer Science, University of Michigan, Ann Arbor, MI, 48109, USA.
György BuzsákiNeuroscience Institute, Langone Medical Center, New York University, New York, NY, 10016, USA.ORCID http://orcid.org/0000-0002-3100-4800
Euisik YoonDepartment of Electrical Engineering and Computer Science, University of Michigan, Ann Arbor, MI, 48109, USA. esyoon@umich.edu.

Funding

Brain rhythms-assisted memory enhancementR01MH107396 · NIMH · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI BUZSAKI, GYORGY, DEVINSKY, ORRIN · 2015 to 2019
$3.3M
Towards a Complete Description of the Circuitry Underlying Memory replay.U01NS090583 · NINDS · UNIVERSITY OF CALIFORNIA-IRVINE · PI SOLTESZ, IVAN · 2014 to 2016
$2.1M
Modular High-Density Optoelectrodes for Local Circuit Analysis - Administrative SupplementU01NS090526 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BUZSAKI, GYORGY, WISE, KENSALL DAVID · 2014 to 2016
$2.0M
NIMH NIH HHS R01 MH107396NINDS NIH HHS U01 NS090526NINDS NIH HHS U01 NS090583
6 · The paper itself

Abstract

The combination of in vivo extracellular recording and genetic-engineering-assisted optical stimulation is a powerful tool for the study of neuronal circuits. Precise analysis of complex neural circuits requires high-density integration of multiple cellular-size light sources and recording electrodes. However, high-density integration inevitably introduces stimulation artifact. We present minimal-stimulation-artifact (miniSTAR) μLED optoelectrodes that enable effective elimination of stimulation artifact. A multi-metal-layer structure with a shielding layer effectively suppresses capacitive coupling of stimulation signals. A heavily boron-doped silicon substrate silences the photovoltaic effect induced from LED illumination. With transient stimulation pulse shaping, we reduced stimulation artifact on miniSTAR μLED optoelectrodes to below 50 μV

Indexed as

ArtifactsElectrophysiological PhenomenaOptogeneticsAnimalsBrainElectrodesElectromagnetic FieldsLightMaleMice, Inbred C57BL

Identifiers

PMID32345971
PMCPMC7188816

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.