ArticleProceedings of the National Academy of Sciences of the United States of America2020
The evolutionary scaling of cellular traits imposed by the drift barrier.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed.
- How Binding Affinity and Binding Specificity Map to Sequence Space.Journal of molecular evolution · 2026Article
- Deceleration and rebound of hemagglutinin divergence in influenza B/Victoria across COVID-19 NPI phases (2016-2024).Frontiers in microbiology · 2026Article
- Evolving a Field: Can Evolutionary Theory Provide What the Study of Human Evolution Requires?American journal of biological anthropology · 2025Review
- Eukaryogenesis From FECA to LECA: Radical Steps Along the Way.BioEssays : news and reviews in molecular, cellular and developmental biology · 2025Review
- Alternative Mutational Architectures Producing Identical M-Matrices can Lead to Different Patterns of Evolutionary Divergence.Genome biology and evolution · 2025Article
- Population size interacts with reproductive longevity to shape the germline mutation rate.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Article
- Population size interacts with reproductive longevity to shape the germline mutation rate.bioRxiv : the preprint server for biology · 2024Article
- Unifying approaches from statistical genetics and phylogenetics for mapping phenotypes in structured populations.PLoS biology · 2024Article
- Genetic and selective constraints on the optimization of gene product diversity.bioRxiv : the preprint server for biology · 2024Article
- Evolutionary Insights from a Large-Scale Survey of Population-Genomic Variation.Molecular biology and evolution · 2023Article
- On the Decoupling of Evolutionary Changes in mRNA and Protein Levels.Molecular biology and evolution · 2023Article
- Article
- Evolutionary Insights from a Large-scale Survey of Population-genomic Variation.bioRxiv : the preprint server for biology · 2023Article
- Decoupling of evolutionary changes in mRNA and protein levels.bioRxiv : the preprint server for biology · 2023Article
- Evolutionary scaling of maximum growth rate with organism size.Scientific reports · 2022Article
- Cell types as species: Exploring a metaphor.Frontiers in plant science · 2022Review
- Independent accretion of TIM22 complex subunits in the animal and fungal lineages.F1000Research · 2020Article
- Expression Partitioning of Duplicate Genes at Single Cell Resolution inFrontiers in genetics · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
Owing to internal homeostatic mechanisms, cellular traits may experience long periods of stable selective pressures, during which the stochastic forces of drift and mutation conspire to generate variation. However, even in the face of invariant selection, the drift barrier defined by the genetic effective population size, which is negatively associated with organism size, can have a substantial influence on the location and dispersion of the long-term steady-state distribution of mean phenotypes. In addition, for multilocus traits, the multiplicity of alternative, functionally equivalent states can draw mean phenotypes away from selective optima, even in the absence of mutation bias. Using a framework for traits with an additive genetic basis, it is shown that 1) optimal phenotypic states may be only rarely achieved; 2) gradients of mean phenotypes with respect to organism size (i.e., allometric relationships) are likely to be molded by differences in the power of random genetic drift across the tree of life; and 3) for any particular set of population-genetic conditions, significant variation in mean phenotypes may exist among lineages exposed to identical selection pressures. These results provide a potentially useful framework for understanding numerous aspects of cellular diversification and illustrate the risks of interpreting such variation in a purely adaptive framework.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.