Evidence map›Paper›PMID 32345657›Full record

ArticleDevelopment (Cambridge, England)2020

Fgf-driven Tbx protein activities directly induce

Daniel P S Osborn, Kuoyu Li, Stephen J Cutty, Andrew C Nelson, Fiona C Wardle, Yaniv Hinits, Simon M Hughes

Open access · hybridAbstract read
In one paragraph

Article in Development (Cambridge, England), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Conservation ofCells · 2024
    Article
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  4. Article
  5. Review
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  9. Review
  10. Article
  11. Article
  12. Evolution of Somite Compartmentalization: A View FromFrontiers in cell and developmental biology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Daniel P S OsbornRandall Centre for Cell and Molecular Biophysics, New Hunt's House, Guy's Campus, King's College London, SE1 1UL, UK.ORCID 0000-0002-5266-404X
Kuoyu LiRandall Centre for Cell and Molecular Biophysics, New Hunt's House, Guy's Campus, King's College London, SE1 1UL, UK.
Stephen J CuttyRandall Centre for Cell and Molecular Biophysics, New Hunt's House, Guy's Campus, King's College London, SE1 1UL, UK.ORCID 0000-0002-2750-0932
Andrew C NelsonRandall Centre for Cell and Molecular Biophysics, New Hunt's House, Guy's Campus, King's College London, SE1 1UL, UK.ORCID 0000-0003-1311-8051
Fiona C WardleRandall Centre for Cell and Molecular Biophysics, New Hunt's House, Guy's Campus, King's College London, SE1 1UL, UK.ORCID 0000-0001-5444-1889
Yaniv HinitsRandall Centre for Cell and Molecular Biophysics, New Hunt's House, Guy's Campus, King's College London, SE1 1UL, UK.ORCID 0000-0002-2682-1603
Simon M HughesRandall Centre for Cell and Molecular Biophysics, New Hunt's House, Guy's Campus, King's College London, SE1 1UL, UK s.hughes@kcl.ac.uk.ORCID 0000-0001-8227-9225
King's College London · GB

Funding

British Heart Foundation PG/13/19/30059British Heart Foundation PG/14/12/30664Medical Research Council G0300213Medical Research Council G0700213Medical Research Council G1001029Medical Research Council MR/N021231/1
6 · The paper itself

Abstract

Skeletal muscle derives from dorsal mesoderm formed during vertebrate gastrulation. Fibroblast growth factor (Fgf) signalling cooperates with Tbx transcription factors to promote dorsal mesoderm formation, but their role in myogenesis has been unclear. Using zebrafish, we show that dorsally derived Fgf signals act through Tbx16 and Tbxta to induce slow and fast trunk muscle precursors at distinct dorsoventral positions. Tbx16 binds to and directly activates the

Indexed as

Muscle DevelopmentAnimalsBody PatterningEmbryo, NonmammalianFibroblast Growth FactorsGene Expression Regulation, DevelopmentalHedgehog ProteinsMyoD ProteinSignal TransductionT-Box Domain ProteinsTranscription, GeneticUp-RegulationZebrafishZebrafish ProteinsFibroblast Growth FactorsHedgehog ProteinsMyoD ProteinT-Box Domain Proteinstbx16 protein, zebrafishZebrafish ProteinsFgfHedgehogMuscleMyf5MyodMyogeninMyosinNtlSptTbx16TbxtaZebrafish

Identifiers

PMID32345657
PMCPMC7197714
OpenAlexW3017511136

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.