Evidence map›Paper›PMID 32345645›Full record

ArticlemBio2020

Optimization of an Experimental Vaccine To Prevent Escherichia coli Urinary Tract Infection.

Valerie S Forsyth, Stephanie D Himpsl, Sara N Smith, Christina A Sarkissian, Laura A Mike, Jolie A Stocki, Anna Sintsova, Christopher J Alteri, Harry L T Mobley

Open access · goldAbstract read
In one paragraph

Article in mBio, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
7.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 49 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Recent advances in enterotoxin vaccine adjuvants.Current opinion in immunology · 2023
    Review
  9. Article
  10. Review
  11. Uropathogen and host responses in pyelonephritis.Nature reviews. Nephrology · 2023
    Review
  12. UropathogenicMicroorganisms · 2023
    Review
  13. Review
  14. Chemical science · 2023
    Article
  15. Review
  16. Article
  17. The Diversity ofMicroorganisms · 2023
    Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Valerie S ForsythDepartment of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan, USA.
Stephanie D HimpslDepartment of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan, USA.
Sara N SmithDepartment of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan, USA.
Christina A SarkissianDepartment of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan, USA.
Laura A MikeDepartment of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan, USA.
Jolie A StockiDepartment of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan, USA.
Anna SintsovaDepartment of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan, USA.
Christopher J AlteriDepartment of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan, USA.
Harry L T MobleyDepartment of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan, USA hmobley@umich.edu.
University of Michigan–Ann Arbor · US

Funding

Vaccine to prevent E. coli urinary tract infectionR01AI116791 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MOBLEY, HARRY L. · 2016 to 2020
$2.0M
Vaccine to prevent E. coli urinary tract infectionR56AI116791 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MOBLEY, HARRY L. · 2021 to 2021
$423k
NIAID NIH HHS R01 AI116791NIAID NIH HHS R56 AI116791
6 · The paper itself

Abstract

Urinary tract infections (UTI) affect half of all women at least once during their lifetime. The rise in the numbers of extended-spectrum beta-lactamase-producing strains and the potential for carbapenem resistance within uropathogenic

Indexed as

Administration, IntranasalAdjuvants, ImmunologicAnimalsAntibodies, BacterialBacterial Outer Membrane ProteinsDrug Administration RoutesEscherichia coli InfectionsEscherichia coli ProteinsFemaleHumansImmunizationMiceReceptors, Cell SurfaceUrinary Tract InfectionsUropathogenic Escherichia coliVaccinationAdjuvants, ImmunologicAntibodies, BacterialBacterial Outer Membrane ProteinsEscherichia coli ProteinsFyuA protein, E coliIreA protein, E coliiutA protein, E coliReceptors, Cell SurfaceVaccinesalumCpGdmLTEscherichia coliFyuAHmaIreAIutAMPLApolyICurinary tract infectionvaccine

Identifiers

PMID32345645
PMCPMC7188996
OpenAlexW3020680721

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.