Evidence map›Paper›PMID 32345316›Full record

ArticleJournal of neuroinflammation2020

Novel alterations in corneal neuroimmune phenotypes in mice with central nervous system tauopathy.

Haihan Jiao, Laura E Downie, Xin Huang, Mengliang Wu, Sara Oberrauch, Ryan J Keenan, Laura H Jacobson, Holly R Chinnery

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neuroinflammation, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Redefining the human corneal immune compartment using dynamic intravital imaging.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  5. Article
  6. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Haihan JiaoDepartment of Optometry and Vision Sciences, The University of Melbourne, Parkville, Australia.
Laura E DownieDepartment of Optometry and Vision Sciences, The University of Melbourne, Parkville, Australia.
Xin HuangInnate Phagocytosis Laboratory, Florey Institute of Neuroscience and Mental Health, Parkville, Australia.
Mengliang WuDepartment of Optometry and Vision Sciences, The University of Melbourne, Parkville, Australia.
Sara OberrauchDepartment of Pharmacology and Therapeutics, The University of Melbourne, Parkville, Australia.
Ryan J KeenanDepartment of Pharmacology and Therapeutics, The University of Melbourne, Parkville, Australia.
Laura H JacobsonDepartment of Pharmacology and Therapeutics, The University of Melbourne, Parkville, Australia. laura.jacobson@florey.edu.au.
Holly R ChinneryDepartment of Optometry and Vision Sciences, The University of Melbourne, Parkville, Australia. holly.chinnery@unimelb.edu.au.
University of Melbourne · AUFlorey Institute of Neuroscience and Mental Health · AUAustralian College of Optometry · AU

Funding

National Health and Medical Research Council Australia APP1126540University of Melbourne Medicine, Dentistry and Health Sciences Seed Funding NA
6 · The paper itself

Abstract

backgroundTauopathy in the central nervous system (CNS) is a histopathological hallmark of frontotemporal dementia (FTD) and Alzheimer's disease (AD). Although AD is accompanied by various ocular changes, the effects of tauopathy on the integrity of the cornea, which is densely innervated by the peripheral nervous system and is populated by resident dendritic cells, is still unknown. The aim of this study was to investigate if neuroimmune interactions in the cornea are affected by CNS tauopathy.

methodsCorneas from wild type (WT) and transgenic rTg4510 mice that express the P301L tau mutation were examined at 2, 6, 8, and 11 months. Clinical assessment of the anterior segment of the eye was performed using spectral domain optical coherence tomography. The density of the corneal epithelial sensory nerves and the number and field area of resident epithelial dendritic cells were assessed using immunofluorescence. The immunological activation state of corneal and splenic dendritic cells was examined using flow cytometry and compared between the two genotypes at 9 months of age.

resultsCompared to age-matched WT mice, rTg4510 mice had a significantly lower density of corneal nerve axons at both 8 and 11 months of age. Corneal nerves in rTg4510 mice also displayed a higher percentage of beaded nerve axons and a lower density of epithelial dendritic cells compared to WT mice. From 6 months of age, the size of the corneal dendritic cells was significantly smaller in rTg4510 compared to WT mice. Phenotypic characterization by flow cytometry demonstrated an activated state of dendritic cells (CD86

conclusionsCorneal sensory nerves and epithelial dendritic cells were altered in the rTg4510 mouse model of tauopathy, with temporal changes observed with aging. The activation of corneal dendritic cells prior to the gradual loss of neighboring sensory nerves suggests an early involvement of corneal immune cells in tau-associated pathology originating in the CNS.

Indexed as

AnimalsCorneaDendritic CellsFemaleMaleMiceMice, TransgenicOphthalmic NervePhenotypeTauopathiesCentral nervous system tauopathyCorneaImmune cellsPeripheral nervous systemSensory nerves

Identifiers

PMID32345316
PMCPMC7189727
OpenAlexW3017402327

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.