ArticleBMC geriatrics2020
Ocular biomarkers for cognitive impairment in nonagenarians; a prospective cross-sectional study.
Article in BMC geriatrics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.
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Who cites it
11 citing papers in PubMed, 2 syntheses or guidelines pooled it, 13 citations in OpenAlex.
- A Systematic Review on Retinal Biomarkers to Diagnose Dementia from OCT/OCTA Images.Journal of Alzheimer's disease reports · 2023Pooled it
- Association between retinal markers and cognition in older adults: a systematic review.BMJ open · 2022Pooled it
- Comparison of the additive value of blood-based and retinal biomarkers to clinical features in predicting cognitive decline.Communications medicine · 2025Article
- Pathological Mechanisms and Molecular Imaging Advances in Alzheimer's Disease.Clinical interventions in aging · 2025Review
- The association of global vessel width with cognitive decline and cerebral small vessel disease burden in the KaiLuan study.Quantitative imaging in medicine and surgery · 2024Article
- Machine learning based on Optical Coherence Tomography images as a diagnostic tool for Alzheimer's disease.CNS neuroscience & therapeutics · 2022Article
- Ocular Vascular Changes: Choroidal Thickness as an Early Biomarker for Alzheimer's Disease?Journal of personalized medicine · 2021Article
- Association of tear fluid amyloid and tau levels with disease severity and neurodegeneration.Scientific reports · 2021Observational
- Longitudinal retinal layer changes in preclinical Alzheimer's disease.Acta ophthalmologica · 2021Article
- Using Optical Coherence Tomography to Screen for Cognitive Impairment and Dementia.Journal of Alzheimer's disease : JAD · 2021Article
- Retinal thickness is associated with global cognition and executive function in mild cognitive impairment due to Alzheimer's disease.Journal of Alzheimer's disease reportsArticle
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Authors and funding
12 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundOcular imaging receives much attention as a source of potential biomarkers for dementia. In the present study, we analyze these ocular biomarkers in cognitively impaired and healthy participants in a population aged over 90 years (= nonagenarian), and elucidate the effects of age on these biomarkers.
methodsFor this prospective cross-sectional study, we included individuals from the EMIF-AD 90+ study, consisting of a cognitively healthy (N = 67) and cognitively impaired group (N = 33), and the EMIF-AD PreclinAD study, consisting of cognitively healthy controls aged ≥60 (N = 198). Participants underwent Optical Coherence Tomography (OCT) and fundus photography of both eyes. OCT was used to asses total and individual inner retinal layer thickness in the macular region (Early Treatment Diabetic Retinopathy Study circles) as well as peripapillary retinal nerve fiber layer thickness, fundus images were analyzed with Singapore I Vessel Assessment to obtain 7 retinal vascular parameters. Values for both eyes were averaged. Differences in ocular biomarkers between the 2 nonagenarian groups were analyzed using linear regression, differences between the individual nonagenarian groups and controls were analyzed using generalized estimating equations.
resultsOcular biomarkers did not differ between the healthy and cognitively impaired nonagenarian groups. 19 out of 22 ocular biomarkers assessed in this study differed between either nonagenarian group and the younger controls.
conclusionThe ocular biomarkers assessed in this study were not associated with cognitive impairment in nonagenarians, making their use as a screening tool for dementing disorders in this group limited. However, ocular biomarkers were significantly associated with chronological age, which were very similar to those ascribed to occur in Alzheimer's Disease.
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