ArticleTherapeutic advances in respiratory disease
Quantitative measurement properties and score interpretation of the Cough Severity Diary in patients with chronic cough.
Article in Therapeutic advances in respiratory disease. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- Guideline
- Psychometric validation of the severity of chronic cough diary, leicester cough questionnaire, and a cough severity visual analogue scale in patients with refractory chronic cough.Journal of patient-reported outcomes · 2025Trial
- Trial
- Trial
- Trial
- Leicester Cough Questionnaire validation and clinically important thresholds for change in refractory or unexplained chronic cough.Therapeutic advances in respiratory diseaseTrial
- Validation of a visual analog scale for assessing cough severity in patients with chronic cough.Therapeutic advances in respiratory diseaseTrial
- AI-Based Respiratory Monitoring-Guided Evaluation of Rottlerin Therapy for PRRS in Grower-Finisher Pig Farms.Viruses · 2026Article
- Clinical Efficacy of Acupuncture as Adjunctive Therapy for Cough Variant Asthma: Study Protocol for a Pilot Randomized Controlled Trial.Journal of asthma and allergy · 2026Article
- The McMaster Cough Severity Questionnaire (MCSQ): a cough severity instrument for patients with refractory chronic cough.The European respiratory journal · 2025Article
- Automated Cough Analysis with Convolutional Recurrent Neural Network.Bioengineering (Basel, Switzerland) · 2024Article
- Patient-reported assessments of chronic cough in clinical trials: accessory or primary endpoints?Journal of thoracic disease · 2024Review
- Development and validation of a novel questionnaire to describe and assess sensations and triggers associated with refractory and unexplained chronic cough.BMJ open respiratory research · 2024Article
- Burden of refractory and unexplained chronic cough on patients' lives: a cohort study.ERJ open research · 2023Article
- Efficacy and Safety of Gefapixant for Refractory or Unexplained Chronic Cough over 52 Weeks.American journal of respiratory and critical care medicine · 2023Article
- Chronic cough-the limitation and advances in assessment techniques.Journal of thoracic disease · 2022Review
- Treatment with the P2X3-Receptor Antagonist Gefapixant for Acute Cough in Induced Viral Upper Respiratory Tract Infection: A Phase 2a, Randomized, Placebo-Controlled Trial.Pulmonary therapy · 2022Article
- Assessing cough symptom severity in refractory or unexplained chronic cough: findings from patient focus groups and an international expert panel.ERJ open research · 2022Article
- Chronic cough: new insights and future prospects.European respiratory review : an official journal of the European Respiratory Society · 2021Review
- Cough symptom severity in patients with refractory or unexplained chronic cough: a systematic survey and conceptual framework.European respiratory review : an official journal of the European Respiratory Society · 2021Review
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsThe Cough Severity Diary (CSD) was developed in accordance with the FDA guidance for patient-reported outcome measures and is focused on capturing the patient's perception of cough in terms of frequency, intensity, and disruption due to their cough. The measure includes a series of seven items asking patients to rate the frequency (three items), intensity (two items), and disruptiveness (two items) of their cough. The instrument was designed to be completed daily before bedtime, has a recall period of 'today,' and responses to items are entered on an 11-point numeric rating scale ranging from 0 to 10 with anchors on each end. The objective of this analysis was to confirm the domain structure of the CSD and assess its reliability, validity, and responsiveness in adult patients with refractory or unexplained chronic cough (RCC/UCC). Criteria for defining meaningful changes in mean weekly CSD total and domain scores in the context of a clinical trial were also developed.
methodsPooled data from a phase II randomized controlled trial of an investigational treatment for RCC/UCC were analyzed. Participants were non-smokers, had RCC/UCC for ⩾1 year, and a baseline cough severity visual analogue scale (VAS) ⩾40 mm. CSD scores (baseline, week 4), were analyzed; the Leicester Cough Questionnaire (LCQ), cough severity VAS, Patient Global Impression of Change (PGIC), and objective cough frequency counts were used for validation. CSD domain structure (Total, Frequency, Intensity, Disruption) was assessed for scoring.
resultsA total of 253 participants were included (mean age 60.2; 76% female). Global fit of the three-factor CSD was acceptable. For the CSD total score, internal consistency (α = 0.89) and test-retest reliability (intraclass correlation coefficient = 0.68) were high. CSD total scores were correlated with the LCQ total (
conclusionThe CSD is a reliable, valid, and responsive measure of cough symptom severity in patients with refractory or unexplained chronic cough and fit-for-purpose for assessing changes in cough severity in clinical trials.
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