Evidence map›Paper›PMID 32345133›Full record

SynthesisJournal of the American Heart Association2020

Association of Isolated Coronary Microvascular Dysfunction With Mortality and Major Adverse Cardiac Events: A Systematic Review and Meta-Analysis of Aggregate Data.

Mark A Gdowski, Venkatesh L Murthy, Michelle Doering, Andrea G Monroy-Gonzalez, Riemer Slart, David L Brown

Open access · goldAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of the American Heart Association, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 101 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
101citing papers in PubMed, 9 pooled it
11.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

101 citing papers in PubMed, 9 syntheses or guidelines pooled it, 155 citations in OpenAlex.

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  11. Angiography-Derived Index of Microcirculatory Resistance (Angio-IMR) Is Associated With Doppler-Derived Hyperemic Microvascular Resistance.Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions · 2026
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41 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Mark A GdowskiCardiovascular Division Washington University School of Medicine St. Louis MO.
Venkatesh L MurthyFrankel Cardiovascular Center University of Michigan Ann Arbor MI.
Michelle DoeringWashington University School of Medicine St. Louis MO.
Andrea G Monroy-GonzalezMedical Imaging Center Departments of Nuclear Medicine and Molecular Imaging and Radiology University of Groningen University Medical Center Groningen the Netherlands.
Riemer SlartMedical Imaging Center Departments of Nuclear Medicine and Molecular Imaging and Radiology University of Groningen University Medical Center Groningen the Netherlands.
David L BrownCardiovascular Division Washington University School of Medicine St. Louis MO.
Washington University in St. Louis · USUniversity Medical Center Groningen · NLUniversity of Michigan · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background The impact of coronary microvascular dysfunction (CMD), as diagnosed by reduced coronary flow reserve, on the outcomes of patients with symptoms of myocardial ischemia and nonobstructive coronary artery disease is poorly understood. We performed a systematic review and meta-analysis of observational studies to determine the association of CMD with outcomes. Methods and Results We searched online databases for studies where coronary flow reserve was measured invasively or noninvasively, clinical events were recorded after determination of coronary flow reserve, and the frequency of those events was reported for patients with and without CMD. The primary outcome was all-cause mortality. The secondary outcome was major adverse cardiac events, including cardiac or cardiovascular death, nonfatal myocardial infarction, cardiac hospitalization, or coronary revascularization. Estimates of effect were calculated from crude event rates with a random-effects model. There were 122 deaths in the 4661 patients without CMD (2.6%) and 183 deaths in the 1970 patients with CMD (9.3%). The odds ratio for mortality in patients with CMD compared with those without CMD was 3.93 (95% CI, 2.91-5.30;

Indexed as

Fractional Flow Reserve, MyocardialMicrocirculationAgedCause of DeathCoronary Artery DiseaseCoronary VesselsFemaleHumansMaleMiddle AgedPrognosisRisk AssessmentRisk Factorscoronary flow reservecoronary microvascular dysfunctionmeta‐analysisoutcomes

Identifiers

PMID32345133
PMCPMC7428565
OpenAlexW3017579290

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.