Evidence map›Paper›PMID 32344933›Full record

ArticleMicroorganisms2020

Antimicrobial Peptides from Rat-Tailed Maggots of the Drone Fly

Rolf Hirsch, Jochen Wiesner, Armin Bauer, Alexander Marker, Heiko Vogel, Peter Eugen Hammann, Andreas Vilcinskas

Open access · goldAbstract read
In one paragraph

Article in Microorganisms, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.3field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 1 country.

Rolf HirschFraunhofer Institute for Molecular Biology and Applied Ecology, Department of Bioresources, Ohlebergsweg 12, 35392 Giessen, Germany.
Jochen WiesnerFraunhofer Institute for Molecular Biology and Applied Ecology, Department of Bioresources, Ohlebergsweg 12, 35392 Giessen, Germany.
Armin BauerSanofi-Aventis Deutschland GmbH, Industriepark Höchst, 65926 Frankfurt, Germany.
Alexander MarkerSanofi-Aventis Deutschland GmbH, Industriepark Höchst, 65926 Frankfurt, Germany.
Heiko VogelMax-Planck Institute for Chemical Ecology, Department of Entomology, Hans-Knoell-Strasse 8, 07745 Jena, Germany.
Peter Eugen HammannEvotec International GmbH, Marie-Curie-Str. 7, 37079 Göttingen, Germany.
Andreas VilcinskasFraunhofer Institute for Molecular Biology and Applied Ecology, Department of Bioresources, Ohlebergsweg 12, 35392 Giessen, Germany.
Evotec (Germany) · DESanofi (Germany) · DEFraunhofer Institute for Molecular Biology and Applied Ecology · DEJustus-Liebig-Universität Gießen · DEMax Planck Institute for Chemical Ecology · DE

Funding

Bundesministerium für Bildung und Forschung 16GW0126Hesse State Ministry of Higher Education, Research and the Arts LOEWE Center for Insect Biotechnology and Bioresources
6 · The paper itself

Abstract

The spread of multidrug-resistant Gram-negative bacteria is an increasing threat to human health, because novel compound classes for the development of antibiotics have not been discovered for decades. Antimicrobial peptides (AMPs) may provide a much-needed breakthrough because these immunity-related defense molecules protect many eukaryotes against Gram-negative pathogens. Recent concepts in evolutionary immunology predict the presence of potent AMPs in insects that have adapted to survive in habitats with extreme microbial contamination. For example, the saprophagous and coprophagous maggots of the drone fly

Indexed as

antibioticantimicrobial peptidesEristalis tenaxGram-negative bacteriainnate immunitytranscriptomics

Identifiers

PMID32344933
PMCPMC7284870
OpenAlexW3018486952

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.