ArticleBiosensors2020
Host-Modulation Therapy and Chair-Side Diagnostics in the Treatment of Peri-Implantitis.
Article in Biosensors, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 29 citations in OpenAlex.
- Fermented lingonberry juice's effects on active MMP-8 (aMMP-8), bleeding on probing (BOP), and visible plaque index (VPI) in dental implants-A clinical pilot mouthwash study.Clinical and experimental dental research · 2022Trial
- Point-of-Care Biomarker Monitoring of Treatment Efficacy: Changes in Mouthrinse Active Matrix Metalloproteinase-8 (aMMP-8) Concentrations Following Periodontal Anti-Infective Treatment.International journal of dentistry · 2026Article
- The Effect of Fermented Lingonberry Spray on Oral Health-A Pilot Study.Dentistry journal · 2025Article
- Sleep deficiency exacerbates periodontal inflammation via trigeminal TRPV1 neurons.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Monitoring of Nonsurgical Treatment of Peri-Implantitis Traditional Measurement Methods and aMMP-8 Test Technology: A Pilot Study.International journal of dentistry · 2025Article
- Evaluating salivary MMP-8 as a biomarker for periodontal diseases: A systematic review and meta-analysis.Heliyon · 2024Article
- Immune cell composition and inflammatory profile of human peri-implantitis and periodontitis lesions.Clinical and experimental immunology · 2024Article
- Diagnostic value of aMMP-8 and azurocidin in peri-implant sulcular fluid as biomarkers of peri-implant health or disease.Clinical and experimental dental research · 2024Article
- Review
- Active MMP-8 as a Biomarker of Peri-implant Health or Disease.European journal of dentistry · 2023Article
- Peri-implant diseases diagnosis, prognosis and dental implant monitoring: a narrative review of novel strategies and clinical impact.BMC oral health · 2023Review
- Antibacterial and Anti-Inflammatory Properties of a Novel Antimicrobial Peptide Derived from LL-37.Antibiotics (Basel, Switzerland) · 2022Article
- Active MMP-8 point-of-care (PoC)/chairside enzyme-test as an adjunctive tool for early and real-time diagnosis of peri-implantitis.Clinical and experimental dental research · 2022Article
- aMMP-8 Oral Fluid PoC Test in Relation to Oral and Systemic Diseases.Frontiers in oral health · 2022Review
- Active matrix metalloproteinase-8 (aMMP-8) point-of-care test (POCT) in the COVID-19 pandemic.Expert review of proteomics · 2021Review
- Free amino acid composition of saliva in patients with healthy periodontium and periodontitis.Clinical oral investigations · 2021Article
- Identification of Potential Genetic Biomarkers and Target Genes of Peri-Implantitis Using Bioinformatics Tools.BioMed research international · 2021Article
- Diagnostic Accuracy of Oral Fluids Biomarker Profile to Determine the Current and Future Status of Periodontal and Peri-Implant Diseases.Diagnostics (Basel, Switzerland) · 2020Review
- Diagnostic Models for Screening of Periodontitis with Inflammatory Mediators and Microbial Profiles in Saliva.Diagnostics (Basel, Switzerland) · 2020Article
- aMMP-8 Point-of-Care/Chairside Oral Fluid Technology as a Rapid, Non-Invasive Tool for Periodontitis and Peri-Implantitis Screening in a Medical Care Setting.Diagnostics (Basel, Switzerland) · 2020Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 2 countries.
Funding
Abstract
Previous studies report periodontitis and peri-implantitis being able to induce systemic low-grade inflammation, which is known to be associated with increased risk for some systemic medical disease such as cardiovascular disease. In this regard, recent studies have shown that host modulation therapy (HMT) together with traditional mechanical and surgical treatment not only cease the progression of periodontitis but also reduce the systemic collagenolytic biomarkers in both oral fluids and circulation. This suggests that the corresponding adjunctive HMT-medication could be effective in the prevention and treatment of dental peri-implantitis, as well. Furthermore, low-cost, safe, and practical oral fluid active matrix metalloproteinase-8 (aMMP-8) lateral-flow immunotests have been proposed as point-of-care/chair-side diagnostic tools to detect peri-implantitis and periodontitis, and to monitor their effective resolutions, while using various therapeutic strategies, including host modulation. This study reports the potential benefits of HMT-medication in the prevention and treatment of dental peri-implantitis among five patients (four of five were current/ex-smokers). In addition, the aMMP-8 point-of-care test diagnosed 20 peri-implantitis and 20 healthy controls correctly. In conclusion, this study and previous studies support the potential effectiveness of HMT-medication(s) and point-of-care/chair-side technologies in the treatment and diagnostics/monitoring of peri-implantitis. However, more studies are needed to further confirm this.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.