ArticleJournal of clinical medicine2020
Speckle Tracking-Derived Left Atrial Stiffness Predicts Clinical Outcome in Heart Failure Patients with Reduced to Mid-Range Ejection Fraction.
Article in Journal of clinical medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 23 citations in OpenAlex.
- Prognostic Relevance of Speckle Tracking-Derived Biatrial Stiffness Index in Patients with Dilated Cardiomyopathy.Journal of clinical medicine · 2026Article
- Impaired left atrial function increases the risk of incident atrial fibrillation and heart failure with preserved ejection fraction in hypertensive patients.BMC cardiovascular disorders · 2026Article
- Left atrial stiffness as a novel echocardiographic parameter of atrial dysfunction in cats with hypertrophic cardiomyopathy: A two-dimensional speckle-tracking study.Veterinary world · 2025Article
- The Evolving Role of Cardiac Imaging in Hypertrophic Cardiomyopathy: Diagnosis, Prognosis, and Clinical Practice.Biomedicines · 2025Review
- Left atrial stiffness index predicts atrial fibrillation risk in heart failure with preserved ejection fraction: a nomogram model.American journal of translational research · 2025Article
- Incremental diagnostic and prognostic utility of left atrial deformation in heart failure using speckle tracking echocardiography.Heart failure reviews · 2024Review
- Effects of canagliflozin on cardiac remodeling and hemodynamic parameters in patients with type 2 diabetes mellitus.Scientific reports · 2023Observational
- Increased Left Atrial Stiffness is Significantly Associated with Paroxysmal Atrial Fibrillation in Diabetic Patients.Diabetes, metabolic syndrome and obesity : targets and therapy · 2023Article
- Prognostic relevance of left atrial function and stiffness in heart failure with preserved ejection fraction patients with and without diabetes mellitus.Frontiers in cardiovascular medicine · 2022Article
- Multi-modality assessment and role of left atrial function as an imaging biomarker in cardiovascular disease.The international journal of cardiovascular imaging · 2021Review
- Current clinical applications of speckle tracking echocardiography for assessment of left atrial function.Journal of echocardiography · 2021Review
- Left atrial stiffness: a novel marker of hypertension-mediated organ damage on the horizon?Hypertension research : official journal of the Japanese Society of Hypertension · 2021Article
- Left atrial stiffness predicts cardiac events in patients with heart failure and reduced ejection fraction: The impact of diabetes.Clinical physiology and functional imaging · 2021Article
- Cardiac Imaging for the Assessment of Left Atrial Mechanics Across Heart Failure Stages.Frontiers in cardiovascular medicine · 2021Review
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
aimLeft atrial stiffness (LASt) is an important marker of cardiac function, especially in patients with heart failure (HF); it explains symptoms on the basis of pressure transfer to the pulmonary circulation. The aim of this study was to evaluate the relationship between LASt and cardiac events (CE) in HF patients with reduced to mid-range ejection fraction.
methodsThe study included 215 consecutive ambulatory HF patients with ejection fraction (EF) < 50% (162 HF reduced EF and 53 HF mid-range EF) of mean age 66 ± 11 years and 24.4% females. Peak LA strain (PALS) was measured by speckle tracking echocardiography and E/e' recorded from the apical four-chamber view. Non-invasive LASt was calculated using the equation: LASt = E/e' ratio/PALS. Documented cardiac events (CE) were HF hospitalization and cardiac death.
resultsDuring a median follow up of 41 ± 34 months, 65 patients (30%) had CE. In multivariate analysis model, only raised LV filling pressure (E/e') (OR = 0.292, (95% CI 0.099 to 0.859),
conclusionIn this cohort of ambulatory HFrEF and HFmrEF patients, LASt proved the most powerful predictor of clinical outcome.
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